Croci, Davide Marco; Wanderer, Stefan; Strange, Fabio; Grüter, Basil E; Casoni, Daniela; Sivanrupan, Sivani; Widmer, Hans Rudolf; Di Santo, Stefano; Fandino, Javier; Mariani, Luigi; Marbacher, Serge (2019). Systemic and CSF Interleukin-1α Expression in a Rabbit Closed Cranium Subarachnoid Hemorrhage Model: An Exploratory Study. Brain Sciences, 9(10) MDPI 10.3390/brainsci9100249
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Systemic and CSF Interleukin-1α Expression in a Rabbit Closed Cranium Subarachnoid Hemorrhage Model An Exploratory Study.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
BACKGROUND
The inflammatory pathway in cerebrospinal fluid (CSF) leads to delayed cerebral vasospasm (DCVS) and delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). The role of IL-1α has never been evaluated in a rabbit SAH model. The aim of our study is to analyze systemic and CSF changes of IL-1α, and to evaluate potential associations with the onset of DCVS in a rabbit closed cranium SAH model. Methods: 17 New Zealand white rabbits were randomized into two groups, SAH (n = 12) and sham (n = 5). In the first group, SAH was induced by extracranial-intracranial shunting from the subclavian artery into the cerebral cistern of magna under intracranial pressure (ICP) monitoring. The sham group served as a control. The CSF and blood samples for IL-1α measurement were taken at day zero before SAH induction and at day three.
RESULTS
There was a significant increase of ICP (p = 0.00009) and a decrease of cerebral perfusion pressure (CPP) (p = 0.00089) during SAH induction. At follow up, there was a significant increase of systemic IL-1α in the SAH as compared with the sham group (p = 0.042). There was no statistically significant difference in the CSF values in both groups. The CSF IL-1α values showed a correlation trend of DCVS.
CONCLUSIONS
Systemic IL-1α levels are elevated after SAH induction in a rabbit SAH model.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Neurochirurgie |
UniBE Contributor: |
Wanderer, Stefan, Casoni, Daniela, Widmer, Hans Rudolf, Di Santo, Stefano |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2076-3425 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Nicole Söll |
Date Deposited: |
14 Jan 2020 09:06 |
Last Modified: |
05 Dec 2022 15:34 |
Publisher DOI: |
10.3390/brainsci9100249 |
PubMed ID: |
31554320 |
Uncontrolled Keywords: |
IL-1α animal model inflammation subarachnoid hemorrhage |
BORIS DOI: |
10.7892/boris.137487 |
URI: |
https://boris.unibe.ch/id/eprint/137487 |
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