Pediatric patients at risk for fever in chemotherapy-induced neutropenia in Bern, Switzerland, 1993-2012.

von Allmen, Annina N; Zermatten, Maxime G; Leibundgut, Kurt; Agyeman, Philipp; Ammann, Roland (2018). Pediatric patients at risk for fever in chemotherapy-induced neutropenia in Bern, Switzerland, 1993-2012. Scientific data, 5, p. 180038. Springer Nature 10.1038/sdata.2018.38

[img]
Preview
Text
sdata201838.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (238kB) | Preview

Fever in neutropenia (FN) is the most frequent potentially life threatening complication of chemotherapy for cancer. Prediction of the risk to develop FN during chemotherapy would allow for targeted prophylaxis. This retrospective, single centre cohort study in pediatric patients diagnosed with cancer before 17 years covered two decades, 1993 to 2012. The 583 (73%) of 800 patients diagnosed with cancer who had received chemotherapy were studied here. Data on 2113 observation periods was collected, defined by stable combinations of 11 predefined characteristics potentially associated with FN. They covered 692 years of cumulative chemotherapy exposure time, during which 712 FN episodes were diagnosed, 154 (22%) of them with bacteremia. The risk to develop FN and FN with bacteremia remained stable over time. These data can mainly be used to study FN risks over time and between centers, and to derive or externally validate FN risk prediction rules.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Haematology/Oncology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Infectiology

UniBE Contributor:

Leibundgut, Kurt; Agyeman, Philipp and Ammann, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2052-4463

Publisher:

Springer Nature

Language:

English

Submitter:

Roland Ammann

Date Deposited:

15 Jan 2020 16:45

Last Modified:

07 Sep 2020 12:01

Publisher DOI:

10.1038/sdata.2018.38

PubMed ID:

29534058

BORIS DOI:

10.7892/boris.137524

URI:

https://boris.unibe.ch/id/eprint/137524

Actions (login required)

Edit item Edit item
Provide Feedback