Bonnemaijer, Pieter W M; Leeuwen, Elisabeth M van; Iglesias, Adriana I; Gharahkhani, Puya; Vitart, Veronique; Khawaja, Anthony P; Simcoe, Mark; Höhn, René; Cree, Angela J; Igo, Rob P; Gerhold-Ay, Aslihan; Nickels, Stefan; Wilson, James F; Hayward, Caroline; Boutin, Thibaud S; Polašek, Ozren; Aung, Tin; Khor, Chiea Chuen; Amin, Najaf; Lotery, Andrew J; ... (2019). Multi-trait genome-wide association study identifies new loci associated with optic disc parameters. Communications biology, 2, p. 435. Springer Nature 10.1038/s42003-019-0634-9
|
Text
s42003-019-0634-9.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
A new avenue of mining published genome-wide association studies includes the joint analysis of related traits. The power of this approach depends on the genetic correlation of traits, which reflects the number of pleiotropic loci, i.e. genetic loci influencing multiple traits. Here, we applied new meta-analyses of optic nerve head (ONH) related traits implicated in primary open-angle glaucoma (POAG); intraocular pressure and central corneal thickness using Haplotype reference consortium imputations. We performed a multi-trait analysis of ONH parameters cup area, disc area and vertical cup-disc ratio. We uncover new variants; rs11158547 in PPP1R36-PLEKHG3 and rs1028727 near SERPINE3 at genome-wide significance that replicate in independent Asian cohorts imputed to 1000 Genomes. At this point, validation of these variants in POAG cohorts is hampered by the high degree of heterogeneity. Our results show that multi-trait analysis is a valid approach to identify novel pleiotropic variants for ONH.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Höhn, René Gerhard Joachim |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2399-3642 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Sebastian Wolf |
Date Deposited: |
14 Jan 2020 09:43 |
Last Modified: |
05 Dec 2022 15:34 |
Publisher DOI: |
10.1038/s42003-019-0634-9 |
PubMed ID: |
31798171 |
Uncontrolled Keywords: |
Genome-wide association studies Optic nerve diseases |
BORIS DOI: |
10.7892/boris.137630 |
URI: |
https://boris.unibe.ch/id/eprint/137630 |
Actions (login required)
 |
Edit item |