Health-Related Quality of Life in Young Adults Following Pediatric Arterial Ischemic Stroke.

Rohner, Aline; Gutbrod, Klemens; Kohler, Barbara; Lidzba, Karen; Fischer, Urs; Goeggel Simonetti, Barbara; Regényi, Mária; Steinlin, Maja; Bigi, Sandra (2020). Health-Related Quality of Life in Young Adults Following Pediatric Arterial Ischemic Stroke. Stroke, 51(3), pp. 952-957. American Heart Association 10.1161/STROKEAHA.119.027622

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Background and Purpose- Pediatric arterial ischemic stroke (AIS) is a rare disease leading to long-lasting neurological sequelae. Little is known about the long-term health-related quality of life (HRQoL) of these patients. The study aims to compare HRQoL in young adults who have had pediatric AIS with a healthy control group. Methods- A cross-sectional study compared self-rated HRQoL, depression, fatigability, and behavior in pediatric stroke survivors to healthy controls. Patients with a confirmed diagnosis of pediatric AIS who were ≥18 years at the time of recruitment and ≥2 years after acute AIS, as well as healthy controls ≥18 years matched for age, sex, and socioeconomic status were included. Primary outcome was HRQoL measured with the Short Form Health Survey. Results- Thirty-three patients (median [interquartile range] aged 22 years [20-26]; 22 males, 67%) and 71 controls (median [interquartile range] aged 23 years [21-25]; 41 males, 58%) were included. Overall, HRQoL, depression, or fatigability did not differ between the patients and the control group. Patients rated themselves lower on the disinhibition scale (P=0.049) and tended to rate themselves lower on the executive dysfunction scale (P=0.076). Patients with a poor outcome 24 months after AIS showed a clear trend toward impairment of executive functioning (P=0.056) and work/productivity in the stroke-specific QoL (P=0.05). Conclusions- Self-rated HRQoL, depression, and fatigability in adult pediatric stroke survivors are comparable to healthy adult peers. A poor outcome 24 months after acute stroke might affect work performance and executive functioning in adulthood.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Gutbrod, Klemens; Kohler, Barbara; Lidzba, Karen; Fischer, Urs; Goeggel Simonetti, Barbara; Regényi, Mária; Steinlin, Maja and Bigi, Sandra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1524-4628

Publisher:

American Heart Association

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

16 Jan 2020 12:04

Last Modified:

26 Feb 2020 01:32

Publisher DOI:

10.1161/STROKEAHA.119.027622

PubMed ID:

31865895

Uncontrolled Keywords:

adult control group depression quality of life stroke survivors

BORIS DOI:

10.7892/boris.137729

URI:

https://boris.unibe.ch/id/eprint/137729

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