Shooting a high-density electroencephalographic picture on sleep in children with attention-deficit/hyperactivity disorder.

Miano, Silvia; Amato, Ninfa; Garbazza, Corrado; Abbafati, Manuel; Foderaro, Giuseppe; Pezzoli, Valdo; Ramelli, Gian Paolo; Manconi, Mauro (2019). Shooting a high-density electroencephalographic picture on sleep in children with attention-deficit/hyperactivity disorder. Sleep, 42(11) Oxford University Press 10.1093/sleep/zsz167

[img] Text
Miano, 2019, Shootin a high_density electroencephalographic picture.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (17MB) | Request a copy

STUDY OBJECTIVES Sleep-related slow-wave activity (SWA) has been recognized as a marker of synaptic plasticity. In children affected by attention deficit hyperactivity disorder (ADHD), SWA is mainly located in the central rather than frontal regions, reflecting a maturational delay. A detailed subjective and objective sleep investigation, including a full night video-polysomnography (PSG-HD-EEG), was performed on 30 consecutive drug naïve outpatients with a diagnosis of ADHD. They received a diagnosis of sleep disorders in 29/30 cases, and most of them had a past history of sleep problems. They had a higher apnea-hypopnea index at PSG, and slept less than 9 hr at actigraphy. We aimed to describe the SWA behavior in the same group of children with ADHD. MATERIALS AND METHODS The full-night PSG-HD EEG of children with ADHD was compared with the one of the 25 healthy controls. The scalp SWA mapping, the decrease of SWA during the night, and the EEG source of SWA were analyzed. RESULTS At scalp topography, the focus of SWA was observed over the centro-parietal-occipital regions in participants with ADHD (p < 0.01), which remained significant in the subgroups divided between subgroups according to the sleep diagnosis (p < 0.01). The physiological decrease in SWA was more evident in control participants. The source analysis revealed a greater delta power over the posterior cingulate in participants with ADHD (p < 0.01). CONCLUSIONS Our results confirm static and dynamic changes in SWA behavior in children with ADHD, which may reflect a maturational delay occurring at a vulnerable age, as a consequence of chronic sleep deprivation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Manconi, Mauro

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1550-9109

Publisher:

Oxford University Press

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

15 Jan 2020 13:04

Last Modified:

15 Jan 2020 13:04

Publisher DOI:

10.1093/sleep/zsz167

PubMed ID:

31353407

Uncontrolled Keywords:

ADHD EEG spectral analysis pediatric psychiatry slow-wave sleep

BORIS DOI:

10.7892/boris.137742

URI:

https://boris.unibe.ch/id/eprint/137742

Actions (login required)

Edit item Edit item
Provide Feedback