Usefulness of platelet-rich fibrin as a hemostatic agent after dental extractions in patients receiving anticoagulant therapy with factor Xa inhibitors: a case series.

de Almeida Barros Mourão, Carlos Fernando; Miron, Richard J.; de Mello Machado, Rafael Coutinho; Ghanaati, Shahram; Alves, Gutemberg Gomes; Calasans-Maia, Mônica Diuana (2019). Usefulness of platelet-rich fibrin as a hemostatic agent after dental extractions in patients receiving anticoagulant therapy with factor Xa inhibitors: a case series. Oral and maxillofacial surgery, 23(3), pp. 381-386. Springer-Verlag 10.1007/s10006-019-00769-y

[img] Text
DeAlmeidaBarrosMourão2019_Article_UsefulnessOfPlatelet-richFibri.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (668kB) | Request a copy

PURPOSE To evaluate the clinical outcomes of platelet-rich fibrin (PRF) application for hemostasis after dental extraction in patients receiving anticoagulant therapy with factor Xa inhibitors. METHODS In total, 25 patients receiving anticoagulant therapy with rivaroxaban or apixaban who required routine dental extraction were evaluated. In all patients, PRF was used for hemostasis in addition to adapting sutures. Bleeding was subjectively assessed using a sterilize gauze pad at 24, 48, and 72 h after the procedure. RESULTS All invited participants (n = 25) consented to participate. The PRF clots successfully arrested bleeding after extraction in all patients, with no complications at any time point after the procedure. Favorable soft tissue healing was observed during suture removal at 10 days after the procedure in all patients, with no signs of infection or late healing. CONCLUSIONS The results of this case series indicate that PRF is a promising natural hemostatic agent for the management of bleeding after dental extraction in patients receiving factor Xa inhibitor therapy. Further controlled clinical studies with larger patient samples are necessary to clarify the findings of this case series.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Miron, Richard John

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1865-1550

Publisher:

Springer-Verlag

Language:

English

Submitter:

Doris Burri

Date Deposited:

20 Jan 2020 10:54

Last Modified:

20 Jan 2020 10:54

Publisher DOI:

10.1007/s10006-019-00769-y

PubMed ID:

31102080

Uncontrolled Keywords:

Anticoagulant therapy Clot stability Dental extraction Hemostasis Platelet-rich fibrin

BORIS DOI:

10.7892/boris.137814

URI:

https://boris.unibe.ch/id/eprint/137814

Actions (login required)

Edit item Edit item
Provide Feedback