Standardization of relative centrifugal forces in studies related to platelet-rich fibrin.

Miron, Richard J.; Pinto, Nelson R; Quirynen, Marc; Ghanaati, Shahram (2019). Standardization of relative centrifugal forces in studies related to platelet-rich fibrin. Journal of periodontology, 90(8), pp. 817-820. American Academy of Periodontology 10.1002/JPER.18-0553

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Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has been the focus of intensive research endeavors over the past 2 decades. Over the years, however, numerous reports have inaccurately reported relative centrifugal force (RCF) values, which has caused considerable confusion in the field. Furthermore, the use of trade names such as leukocyte and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) has further confused many readers, since studies have not always used centrifugation parameters with equal rotor sizes, angulation of tubes, and/or tube design. This has led to considerable misperception in the report of relative centrifugal force. Herein is described necessary parameters pivotal for the future report of RCF in studies related to PRF, which include: 1) dimensions of the rotor (radius at the clot and end of the tube); 2) rotor angulation for the tube holder; 3) revolutions per minute (RPM) and time; 4) RCF value calculated at either the RCF-minimum, RCF-clot, or RCF-maximum; 5) composition and size of tubes used to produce PRF; and 6) centrifugation model used. This editorial aims to minimize confusion in the field and create more transparent research reporting RCF values in future studies.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Miron, Richard John


600 Technology > 610 Medicine & health




American Academy of Periodontology




Doris Burri

Date Deposited:

20 Jan 2020 14:41

Last Modified:

20 Jan 2020 14:41

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

A-PRF L-PRF PRF advanced platelet-rich fibrin leukocyte and platelet-rich fibrin platelet-rich fibrin




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