High betatrophin in coronary patients protects from cardiovascular events.

Leiherer, Andreas; Ebner, Janine; Muendlein, Axel; Brandtner, Eva M; Zach, Christina; Geiger, Kathrin; Fraunberger, Peter; Drexel, Heinz (2020). High betatrophin in coronary patients protects from cardiovascular events. Atherosclerosis, 293, pp. 62-68. Elsevier 10.1016/j.atherosclerosis.2019.11.011

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BACKGROUND AND AIMS Betatrophin, also known as angiopoietin-like protein 8 (ANGPTL8) or lipasin, is a nutritionally-regulated mammalian-specific protein secreted by the liver and adipose tissue. Many conflicting data exist with respect to its association with type 2 diabetes mellitus (T2DM), insulin resistance, and lipid markers, but no data are available on its association with cardiovascular risk. METHODS We measured betatrophin in 553 coronary patients undergoing coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD) and prospectively recorded cardiovascular events during a follow-up of up to 8 years. RESULTS During follow-up, 201 patients suffered a cardiovascular event and 64 died from cardiovascular causes. High betatrophin (upper tertile) was significantly and inversely associated with cardiovascular events both univariately (HR = 0.64 [95%CI 0.47-0.87], p = 0.004) and after full adjustment including the status of CAD and T2DM (adj. HR = 0.55 [95%CI 0.40-0.76], p < 0.001). The inclusion of betatrophin into a basic prediction model for the cardiovascular event risk significantly improved the model performance (NRI = 0.728, p < 0.001). CONCLUSIONS This study is the first to show that betatrophin predicts cardiovascular events independently of conventional risk factors including the presence of CAD and T2DM.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Drexel, Heinz

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0021-9150

Publisher:

Elsevier

Language:

English

Submitter:

Isabel Lorenz

Date Deposited:

08 Jan 2020 09:05

Last Modified:

08 Jan 2020 09:05

Publisher DOI:

10.1016/j.atherosclerosis.2019.11.011

PubMed ID:

31862484

Uncontrolled Keywords:

ANGPTL8 Betatrophin Biomarker Cardiovascular death Cardiovascular events

BORIS DOI:

10.7892/boris.137825

URI:

https://boris.unibe.ch/id/eprint/137825

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