The effect of food on the pharmacokinetics of oral ivermectin.

Duthaler, Urs; Leisegang, Rory; Karlsson, Mats O; Krähenbühl, Stephan; Hammann, Felix (2020). The effect of food on the pharmacokinetics of oral ivermectin. The journal of antimicrobial chemotherapy, 75(2), pp. 438-440. Oxford University Press 10.1093/jac/dkz466

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BACKGROUND

Ivermectin is an older anthelminthic agent that is being studied more intensely given its potential for mass drug administration against scabies, malaria and other neglected tropical diseases. Its pharmacokinetics (PK) remain poorly characterized. Furthermore, the majority of PK trials are performed under fasted-state dosing conditions, and the effect of food is therefore not well known. To better plan and design field trials with ivermectin, a model that can account for both conditions would be valuable.

OBJECTIVES

To develop a PK model and characterize the food effect with single oral doses of ivermectin.

PATIENTS AND METHODS

We performed a population-based PK analysis of data pooled from two previous trials of a single dose of 12 mg ivermectin, one with dosing after a high-fat breakfast (n=12) and one with fasted-state dosing (n=3).

RESULTS

The final model described concentration-time profiles after fed and fasted dosing accurately, and estimated the food effect associated with relative bioavailability to 1.18 (95% CI 1.10-1.67).

CONCLUSIONS

In this analysis, the effect of a high-fat breakfast compared with a fasted-state administration of a single oral dose of 12 mg ivermectin was minimal.

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5 Citations in Web of Science ®
6 Citations in Scopus

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