The role of postoperative thoracic radiotherapy and prophylactic cranial irradiation in early stage small cell lung cancer: Patient selection among ESTRO experts.

Putora, Paul M.; De Ruysscher, Dirk; Glatzer, Markus; Widder, Joachim; Van Houtte, Paul; Troost, Esther G C; Slotman, Ben J; Ramella, Sara; Pöttgen, Christoph; Peeters, Stephanie; Nestle, Ursula; McDonald, Fiona; Le Pechoux, Cecile; Dziadziuszko, Rafal; Belderbos, José; Faivre-Finn, Corinne (2020). The role of postoperative thoracic radiotherapy and prophylactic cranial irradiation in early stage small cell lung cancer: Patient selection among ESTRO experts. Radiotherapy and oncology, 145, pp. 45-48. Elsevier 10.1016/j.radonc.2019.11.022

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BACKGROUND

The role of prophylactic cranial irradiation (PCI) and thoracic radiotherapy (TRT) is unclear in resected small cell lung cancer (SCLC).

METHODS

Thirteen European radiotherapy experts on SCLC were asked to describe their strategies on PCI and TRT for patients with resected SCLC. The treatment strategies were converted into decision trees and analyzed for consensus and discrepancies.

RESULTS

For patients with resected SCLC and positive lymph nodes most experts recommend prophylactic cranial irradiation and thoracic radiotherapy. For elderly patients with resected node negative SCLC, most experts do not recommend thoracic radiotherapy or prophylactic cranial irradiation.

CONCLUSION

PCI and TRT are considered in patients with resected SCLC and these treatments should be discussed with the patient in the context of shared decision-making.

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