Human papilloma virus-associated squamous cell carcinoma of the larynx in an 18-year-old woman.

Hotz, Michael-André; Christen, Brigitte; Sahli, Roland; Arnold, Andreas Michael (2019). Human papilloma virus-associated squamous cell carcinoma of the larynx in an 18-year-old woman. Head & neck, 41(4), E59-E61. Wiley 10.1002/hed.25572

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BACKGROUND Human papilloma virus (HPV)-associated malignancies are considered to be sexually transmitted diseases. METHODS We report a HPV-positive larynx cancer in an 18-year-old female clarinet player, despite vaccination with the quadrivalent HPV-6-11-16-18-vaccine Gardasil (Merck Sharp & Dohme Corp., West Point, Pennsylvania). The patient showed no evidence of genito-oral infection but showed some evidence for oral-oral HPV transmission through the sharing of saliva-infested clarinet mouthpieces. A right vocal cord lesion of benign appearance was removed via free margin resection. RESULTS Histopathology revealed a microinvasive squamous cell carcinoma inside a zone of high-grade dysplasia that was positive for HPV-45. No tumor recurrence was observed during a 4-year follow-up evaluation. CONCLUSION Benign lesion appearance and quadrivalent HPV vaccine status do not exclude HPV-associated malignancies. In our patient, the Gardasil vaccine did not provide crossover protection against HPV 45 infection. HPV-associated disease may not necessarily be transmitted via sexual practice patterns alone.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Hotz, Michael André and Arnold, Andreas Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1043-3074

Publisher:

Wiley

Language:

English

Submitter:

Stefan Weder

Date Deposited:

22 Jan 2020 11:31

Last Modified:

22 Jan 2020 11:40

Publisher DOI:

10.1002/hed.25572

PubMed ID:

30589154

Uncontrolled Keywords:

human papilloma virus larynx squamous cell carcinoma transmission vaccination

BORIS DOI:

10.7892/boris.137954

URI:

https://boris.unibe.ch/id/eprint/137954

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