Stelmes, Jean-Jacques; Gregoire, Vincent; Poorten, Vincent Vander; Golusiñski, Wojciech; Szewczyk, Mateusz; Jones, Terry; Ansarin, Mohssen; Broglie, Martina A; Giger, Roland; Klussmann, Jens Peter; Evans, Mererid; Bourhis, Jean; Leemans, C René; Spriano, Giuseppe; Dietz, Andreas; Hunter, Keith; Zimmermann, Frank; Tinhofer, Ingeborg; Patterson, Joanne M; Quaglini, Silvana; ... (2019). Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial. Frontiers in oncology, 9, p. 999. Frontiers Research Foundation 10.3389/fonc.2019.00999
|
Text
fonc-09-00999.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (389kB) | Preview |
Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality of life in patients with head and neck cancers. Novel surgical and radiation therapy techniques have been developed to better preserve swallowing function, while not negatively influencing local control and/or overall survival. This review focuses on the current literature of swallowing outcomes after curative treatment strategies. Available results from recent studies relevant to this topic are presented, demonstrating the potential role of new treatment modalities for early- and intermediate-stage oropharyngeal cancers. Based on this, we present the rationale and design of the currently active EORTC 1420 "Best of" trial, and highlight the potential of this study to help prioritizing either surgery- or radiation-based treatment modalities for the treatment of oropharyngeal cancer in the future.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) |
UniBE Contributor: |
Giger, Roland |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2234-943X |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Stefan Weder |
Date Deposited: |
22 Jan 2020 12:05 |
Last Modified: |
05 Dec 2022 15:35 |
Publisher DOI: |
10.3389/fonc.2019.00999 |
PubMed ID: |
31696052 |
Uncontrolled Keywords: |
EORTC 1420 functional outcome head and neck cancer organ preservation oropharyngeal cancer |
BORIS DOI: |
10.7892/boris.137964 |
URI: |
https://boris.unibe.ch/id/eprint/137964 |
Actions (login required)
 |
Edit item |