Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial.

Stelmes, Jean-Jacques; Gregoire, Vincent; Poorten, Vincent Vander; Golusiñski, Wojciech; Szewczyk, Mateusz; Jones, Terry; Ansarin, Mohssen; Broglie, Martina A; Giger, Roland; Klussmann, Jens Peter; Evans, Mererid; Bourhis, Jean; Leemans, C René; Spriano, Giuseppe; Dietz, Andreas; Hunter, Keith; Zimmermann, Frank; Tinhofer, Ingeborg; Patterson, Joanne M; Quaglini, Silvana; ... (2019). Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial. Frontiers in oncology, 9, p. 999. Frontiers Research Foundation 10.3389/fonc.2019.00999

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Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality of life in patients with head and neck cancers. Novel surgical and radiation therapy techniques have been developed to better preserve swallowing function, while not negatively influencing local control and/or overall survival. This review focuses on the current literature of swallowing outcomes after curative treatment strategies. Available results from recent studies relevant to this topic are presented, demonstrating the potential role of new treatment modalities for early- and intermediate-stage oropharyngeal cancers. Based on this, we present the rationale and design of the currently active EORTC 1420 "Best of" trial, and highlight the potential of this study to help prioritizing either surgery- or radiation-based treatment modalities for the treatment of oropharyngeal cancer in the future.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Giger, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2234-943X

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Stefan Weder

Date Deposited:

22 Jan 2020 12:05

Last Modified:

26 Jan 2020 02:49

Publisher DOI:

10.3389/fonc.2019.00999

PubMed ID:

31696052

Uncontrolled Keywords:

EORTC 1420 functional outcome head and neck cancer organ preservation oropharyngeal cancer

BORIS DOI:

10.7892/boris.137964

URI:

https://boris.unibe.ch/id/eprint/137964

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