Odor-related brain hyper-reactivity in euthymic bipolar disorder: An fMRI and ERP study.

Negoias, Simona; Chen, Ben; Iannilli, Emilia; Ning, Yuping; Kitzler, Hagen H; Hummel, Thomas; Krüger, Stephanie (2019). Odor-related brain hyper-reactivity in euthymic bipolar disorder: An fMRI and ERP study. Psychiatry research, 278, pp. 218-227. Elsevier 10.1016/j.psychres.2019.06.016

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Previous studies on olfactory function in patients with bipolar disorder (BD) are limited and contradictory. The current study aimed to comprehensively analyze the olfactory function of patients with euthymic BD using psychophysical, electrophysiological and neuroimaging techniques. Twenty-one patients with BD in remission and 20 healthy controls were tested with the "Sniffin' Sticks" olfactory test. Block-design fMRI data to a pleasant and an unpleasant stimulus were acquired while recording intensity and hedonic ratings. Olfactory event-related potentials (OERP) to the same stimuli were additionally recorded. Results show no differences between patients and healthy controls in terms of self-rated olfactory function and tested olfactory domains (odor threshold, discrimination or identification) (p>0.05). Compared to healthy controls, patients showed an increased fMRI activation in multiple cortical and subcortical regions as a response to olfactory stimulation, as well as larger amplitudes of OERPs regardless of the hedonic valence of the odor. All in all, patients with euthymic BD showed a stronger central responsiveness to odorous stimuli in fMRI and OERPs despite of normal psychophysical results, indicating the probable existence of an odor-related over-reactive brain network in the remission phase of BD.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Negoias, Simona Nicoleta


600 Technology > 610 Medicine & health








Stefan Weder

Date Deposited:

22 Jan 2020 10:59

Last Modified:

05 Dec 2022 15:35

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Bipolar disorder FMRI Olfaction Olfactory evoked potentials





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