Consensus-based technical recommendations for clinical translation of renal BOLD MRI.

Bane, Octavia; Mendichovszky, Iosif A; Milani, Bastien; Dekkers, Ilona A; Deux, Jean-Francois; Eckerbom, Per; Grenier, Nicolas; Hall, Michael E; Inoue, Tsutomu; Laustsen, Christoffer; Lerman, Lilach O; Liu, Chunlei; Morrell, Glen; Pedersen, Michael; Pruijm, Menno; Sadowski, Elizabeth A; Seeliger, Erdmann; Sharma, Kanishka; Thoeny, Harriet; Vermathen, Peter; ... (2020). Consensus-based technical recommendations for clinical translation of renal BOLD MRI. Magma, 33(1), pp. 199-215. Springer 10.1007/s10334-019-00802-x

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Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as ≥ 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Abt. Magnetresonanz-Spektroskopie und Methodologie, AMSM
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Vermathen, Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1352-8661

Publisher:

Springer

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

27 Jan 2020 08:15

Last Modified:

10 Jul 2020 09:42

Publisher DOI:

10.1007/s10334-019-00802-x

PubMed ID:

31768797

Uncontrolled Keywords:

BOLD MRI Biomarkers Consensus Imaging Kidney Standardization

BORIS DOI:

10.7892/boris.138074

URI:

https://boris.unibe.ch/id/eprint/138074

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