Placebo-controlled study on the effects of oral administration of Allium sativum L in postweaning piglets

Ayrle, Hannah; Nathues, Heiko; Bieber, Anna; Durrer, Manuela; Quander, Nele; Mevissen, Meike; Walkenhorst, Michael (2019). Placebo-controlled study on the effects of oral administration of Allium sativum L in postweaning piglets. Veterinary record, 184(10), p. 316. British Veterinary Association 10.1136/vr.105131

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Postweaning diarrhoea (PWD) due to Escherichia coli is an economically important disease in pig production. In this placebo-controlled study performed in Switzerland, the effects of oral supplementation of Allium sativum L. (garlic, AS) on performance (bodyweight (BW) and daily weight gain (DWG)) and health (body condition and clinical score) were investigated in postweaning piglets. Piglets (n=600) were randomly assigned to the treatment groups (placebo, AS or colistin) and observed from birth until three weeks postweaning. The treatments were administered for the first two weeks postweaning. Faecal dry matter (FDM) and coliform bacteria on pen level were measured weekly. Data were analysed using generalised mixed-effect models in R. BW and DWG of the AS group were significantly higher compared with placebo in the third week postweaning. No differences in body condition and FDM were observed. The clinical score of AS-treated animals was significantly better compared with the colistin group. About 33 per cent of the piglets of the AS and the placebo group had to be treated with antibiotics due to the occurrence of severe PWD. The major finding of this study showed that AS supplementation increased growth performance and improved clinical health, but did not reduce the incidence and severity of PWD.

Item Type:

Journal Article (Original Article)


05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Pharmacology and Toxicology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Swine Clinic

UniBE Contributor:

Nathues, Heiko and Mevissen, Meike


600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology
500 Science > 580 Plants (Botany)
600 Technology > 610 Medicine & health




British Veterinary Association




Aniela Bittner

Date Deposited:

28 Jan 2020 14:34

Last Modified:

28 Jan 2020 14:35

Publisher DOI:


PubMed ID:





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