Roccio, Marta; Edge, Albert S. B. (2019). Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration. Development, 146(17) The Company of Biologists 10.1242/dev.177188
|
Text
dev177188.full.pdf - Published Version Available under License Publisher holds Copyright. Download (2MB) | Preview |
The development of therapeutic interventions for hearing loss requires fundamental knowledge about the signaling pathways controlling tissue development as well as the establishment of human cell-based assays to validate therapeutic strategies ex vivo Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how they offer for the first time the opportunity to validate drug-based therapies, gene-targeting approaches and cell replacement strategies.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 |
UniBE Contributor: |
Roccio, Marta |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1477-9129 |
Publisher: |
The Company of Biologists |
Language: |
English |
Submitter: |
Stefan Weder |
Date Deposited: |
27 Jan 2020 14:09 |
Last Modified: |
05 Dec 2022 15:35 |
Publisher DOI: |
10.1242/dev.177188 |
PubMed ID: |
31477580 |
Uncontrolled Keywords: |
Hair cells Inner ear Organoids Regeneration Stem cells |
BORIS DOI: |
10.7892/boris.138138 |
URI: |
https://boris.unibe.ch/id/eprint/138138 |
Actions (login required)
 |
Edit item |