Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration.

Roccio, Marta; Edge, Albert S. B. (2019). Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration. Development, 146(17) The Company of Biologists 10.1242/dev.177188

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The development of therapeutic interventions for hearing loss requires fundamental knowledge about the signaling pathways controlling tissue development as well as the establishment of human cell-based assays to validate therapeutic strategies ex vivo Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how they offer for the first time the opportunity to validate drug-based therapies, gene-targeting approaches and cell replacement strategies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50

UniBE Contributor:

Roccio, Marta

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1477-9129

Publisher:

The Company of Biologists

Language:

English

Submitter:

Stefan Weder

Date Deposited:

27 Jan 2020 14:09

Last Modified:

03 Sep 2020 02:30

Publisher DOI:

10.1242/dev.177188

PubMed ID:

31477580

Uncontrolled Keywords:

Hair cells Inner ear Organoids Regeneration Stem cells

BORIS DOI:

10.7892/boris.138138

URI:

https://boris.unibe.ch/id/eprint/138138

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