Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry.

van Mourik, Martijn S; van der Velde, Nathalie; Mannarino, Giulio; Thibodeau, Marie-Pierre; Masson, Jean-Bernard; Santoro, Gennaro; Baan, Jan; Jansen, Sofie; Kurucova, Jana; Thoenes, Martin; Deutsch, Cornelia; Schoenenberger, Andreas W.; Ungar, Andrea; Bramlage, Peter; Vis, M Marije (2019). Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry. Journal of geriatric cardiology, 16(6), pp. 468-477. Science Press 10.11909/j.issn.1671-5411.2019.06.001

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Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan-Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77-470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48-68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41-2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Geriatric Clinic

UniBE Contributor:

Schoenenberger, Andreas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1671-5411

Publisher:

Science Press

Language:

English

Submitter:

Rebecca Rufer

Date Deposited:

30 Jan 2020 16:15

Last Modified:

30 Jan 2020 16:15

Publisher DOI:

10.11909/j.issn.1671-5411.2019.06.001

PubMed ID:

31308839

Uncontrolled Keywords:

Comprehensive geriatric assessment Multidimensional prognostic index Short physical performance battery Silver code Transcatheter aortic valve implantation

URI:

https://boris.unibe.ch/id/eprint/138168

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