The interaction of intestinal microbiota and innate lymphoid cells in health and disease throughout life.

Ganal-Vonarburg, Stephanie C.; Duerr, Claudia U (2020). The interaction of intestinal microbiota and innate lymphoid cells in health and disease throughout life. Immunology, 159(1), pp. 39-51. Wiley-Blackwell 10.1111/imm.13138

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Immunity is shaped by commensal microbiota. From early life onwards, microbes colonize mucosal surfaces of the body and thereby trigger the establishment of immune homeostasis and defense mechanisms. Recent evidence reveals that the family of innate lymphoid cells (ILCs), which are mainly located in mucosal tissues, are essential in the maintenance of barrier functions as well as in the initiation of an appropriate immune response upon pathogenic infection. In this review, we summarize recent insights on the functional interaction of microbiota and ILCs at steady-state and throughout life. Furthermore, we will discuss the interplay of ILCs and the microbiota in mucosal infections focusing on intestinal immunity.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Ganal-Vonarburg, Stephanie

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0019-2805

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Lara Schindler

Date Deposited:

30 Jan 2020 16:29

Last Modified:

30 Jan 2020 16:29

Publisher DOI:

10.1111/imm.13138

PubMed ID:

31777064

Uncontrolled Keywords:

early life infectious diseases innate lymphoid cells microbiota

BORIS DOI:

10.7892/boris.138169

URI:

https://boris.unibe.ch/id/eprint/138169

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