Antibiotic-resistant pathogens in different patient settings and identification of surveillance gaps in Switzerland - a systematic review.

Fulchini, R; Albrich, W C; Kronenberg, A.; Egli, A; Kahlert, C R; Schlegel, M; Kohler, P (2019). Antibiotic-resistant pathogens in different patient settings and identification of surveillance gaps in Switzerland - a systematic review. Epidemiology and infection, 147(e259), e259. Cambridge University Press 10.1017/S0950268819001523

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The prevalence of antimicrobial resistance (AMR) varies significantly among different patient populations. We aimed to summarise AMR prevalence data from screening studies in different patient settings in Switzerland and to identify surveillance gaps. We performed a systematic review, searching Pubmed, MEDLINE, Embase (01/2000-05/2017) and conference proceedings for Swiss studies reporting on carbapenemase-producing Enterobacteriaceae (CPE), extended-spectrum beta-lactamases (ESBL), mobilised colistin-resistance, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) within different patient settings. We identified 2345 references and included 46 studies. For acute care patients, most screening data come from admission screenings, whereas AMR prevalence among hospitalised patients is largely unknown. Universal admission screenings showed ESBL-prevalences of 5-8% and MRSA-prevalences of 2-5%. For targeted screening, ESBL-prevalence ranged from 14-21%; MRSA-prevalence from 1-4%. For refugees, high ESBL (9-24%) and MRSA (16-24%) carriage rates were reported; returning travellers were frequently (68-80%) colonised with ESBL. Screening data for other pathogens, long-term care facility (LTCF) residents and pediatric populations were scarce. This review confirms high ESBL- and MRSA-carriage rates for risk populations in Switzerland. Emerging pathogens (CPE and VRE) and certain populations (inpatients, LTCF residents and children) are understudied. We encourage epidemiologists and public health authorities to consider these findings in the planning of future surveillance studies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Kronenberg, Andreas Oskar

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0950-2688

Publisher:

Cambridge University Press

Language:

English

Submitter:

Siegfried Hektor Hapfelmeier-Balmer

Date Deposited:

31 Jan 2020 09:24

Last Modified:

28 Nov 2020 02:30

Publisher DOI:

10.1017/S0950268819001523

PubMed ID:

31466538

Uncontrolled Keywords:

Antibiotic resistance Gram-negative bacteria Methicillin - S. aureus resistant to (MRSA) Public health Surveillance

BORIS DOI:

10.7892/boris.138185

URI:

https://boris.unibe.ch/id/eprint/138185

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