Insular volume reductions in patients with major depressive disorder

Mutschler, Isabella; Hänggi, Jürgen; Frei, Manuela; Lieb, Roselind; grosse Holforth, Martin; Seifritz, Erich; Spinelli, Simona (2019). Insular volume reductions in patients with major depressive disorder. Neurology, psychiatry and brain research, 33, pp. 39-47. Elsevier 10.1016/j.npbr.2019.06.002

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Background: Major Depressive Disorder (MDD) is one of the most common mental disorders. Converging evidence
suggests that the insula plays an important role in the pathophysiology of MDD. Little is known regarding
in which insula subregion volume alterations occur in patients with MDD.
Methods: We analyzed voxel-based morphometry in T1-weighted MRI scans of unmedicated DSM-IV MDD patients
(n=26) and in age, education, and sex matched healthy controls (HC, n=26). Furthermore, we performed
a quantitative meta-analysis across 14 structural MRI MDD studies by applying the anatomical likelihood
estimation technique to identify concordant volume reductions in MDD in the insula cortex.
Results: We found significantly reduced grey matter volumes (GMV) in patients with MDD compared to HCs in
the left mid-insula and in the right and left caudate nucleus. The left mid-insular volume reduction in our sample
was consistent with the coordinate-based meta-analysis results.
Conclusions: The findings highlight the role of the mid-insula in the psychopathology of MDD. The mid-insula
subregion might be associated with reduced interoceptive abilities in patients with MDD that is the ability to
process information of “how the body feels”. In addition, the caudate nucleus has been described as being part of
a network that mediates emotional and motivational processes which seems to be affected in MDD.

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