Bally, Lia; Gubler, Philipp; Thabit, Hood; Hartnell, Sara; Ruan, Yue; Wilinska, Malgorzata E; Evans, Mark L; Semmo, Mariam; Vogt, Bruno; Coll, Anthony P; Stettler, Christoph; Hovorka, Roman (2019). Fully closed-loop insulin delivery improves glucose control of inpatients with type 2 diabetes receiving hemodialysis. Kidney international, 96(3), pp. 593-596. Elsevier 10.1016/j.kint.2019.03.006
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Inpatient diabetes management of those on hemodialysis poses a major challenge. In a post hoc analysis of a randomized controlled clinical trial, we compared the efficacy of fully automated closed-loop insulin delivery vs. usual care in patients undergoing hemodialysis while in hospital. Compared to control patients receiving conventional subcutaneous insulin therapy, those patients receiving closed-loop insulin delivery significantly increased the proportion of time when a continuous glucose monitor was in the target range of 5.6-10.0 mmol/l by 37.6 percent without increasing the risk of hypoglycemia. Thus, closed-loop insulin delivery offers a novel way to achieve effective and safe glucose control in this vulnerable patient population.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition |
UniBE Contributor: |
Bally, Lia Claudia, Semmo, Mariam, Vogt, Bruno, Stettler, Christoph |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1523-1755 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Regula Maria Schneider |
Date Deposited: |
23 Jan 2020 14:09 |
Last Modified: |
05 Dec 2022 15:35 |
Publisher DOI: |
10.1016/j.kint.2019.03.006 |
PubMed ID: |
31133457 |
Uncontrolled Keywords: |
artificial pancreas closed-loop insulin delivery glucose control hemodialysis |
BORIS DOI: |
10.7892/boris.138356 |
URI: |
https://boris.unibe.ch/id/eprint/138356 |
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