Fully closed-loop insulin delivery improves glucose control of inpatients with type 2 diabetes receiving hemodialysis.

Bally, Lia; Gubler, Philipp; Thabit, Hood; Hartnell, Sara; Ruan, Yue; Wilinska, Malgorzata E; Evans, Mark L; Semmo, Mariam; Vogt, Bruno; Coll, Anthony P; Stettler, Christoph; Hovorka, Roman (2019). Fully closed-loop insulin delivery improves glucose control of inpatients with type 2 diabetes receiving hemodialysis. Kidney international, 96(3), pp. 593-596. Elsevier 10.1016/j.kint.2019.03.006

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Inpatient diabetes management of those on hemodialysis poses a major challenge. In a post hoc analysis of a randomized controlled clinical trial, we compared the efficacy of fully automated closed-loop insulin delivery vs. usual care in patients undergoing hemodialysis while in hospital. Compared to control patients receiving conventional subcutaneous insulin therapy, those patients receiving closed-loop insulin delivery significantly increased the proportion of time when a continuous glucose monitor was in the target range of 5.6-10.0 mmol/l by 37.6 percent without increasing the risk of hypoglycemia. Thus, closed-loop insulin delivery offers a novel way to achieve effective and safe glucose control in this vulnerable patient population.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Bally, Lia Claudia; Semmo, Mariam; Vogt, Bruno and Stettler, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1523-1755

Publisher:

Elsevier

Language:

English

Submitter:

Regula Maria Schneider

Date Deposited:

23 Jan 2020 14:09

Last Modified:

27 Apr 2020 10:04

Publisher DOI:

10.1016/j.kint.2019.03.006

PubMed ID:

31133457

Uncontrolled Keywords:

artificial pancreas closed-loop insulin delivery glucose control hemodialysis

BORIS DOI:

10.7892/boris.138356

URI:

https://boris.unibe.ch/id/eprint/138356

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