Antimicrobial Peptide Dendrimer Chimera

Siriwardena, Thissa N.; Lüscher, Alexandre; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2019). Antimicrobial Peptide Dendrimer Chimera. Helvetica chimica acta, 102(4), e1900034. Wiley 10.1002/hlca.201900034

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We recently reported the discovery of antimicrobial peptide dendrimers (AMPDs) acting by a membrane‐disruptive mechanism against multidrug resistant pathogenic bacteria. Here, we combined amino acid sequence elements from different AMPDs with different activity profiles to form AMPD chimeras. By joining the outer branches of TNS18, an AMPD active against Pseudomonas aeruginosa, Acinetobacter baumannii and methicillin resistant Staphylococcus aureus, with the core of T7, another AMPD active against P. aeruginosa, A. baumannii and Klebsiella pneumoniae, we obtained AMPD chimera DC5 displaying all previously observed activities while retaining a similar mechanism of action. These experiments show that chimera design represents a useful strategy to improve the properties of AMPDs.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Siriwardena, Thissa Appuhamilage; Javor, Sacha and Reymond, Jean-Louis

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0018-019X

Publisher:

Wiley

Language:

English

Submitter:

Sandra Tanja Zbinden Di Biase

Date Deposited:

20 Jan 2020 09:42

Last Modified:

26 Jan 2020 02:49

Publisher DOI:

10.1002/hlca.201900034

BORIS DOI:

10.7892/boris.138369

URI:

https://boris.unibe.ch/id/eprint/138369

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