Gender differences in mortality and quality of life after septic shock: A post-hoc analysis of the ARISE study.

Luethi, Nora; Bailey, Michael; Higgins, Alisa; Howe, Belinda; Peake, Sandra; Delaney, Anthony; Bellomo, Rinaldo (2020). Gender differences in mortality and quality of life after septic shock: A post-hoc analysis of the ARISE study. Journal of critical care, 55, pp. 177-183. Elsevier 10.1016/j.jcrc.2019.11.002

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PURPOSE To assess the impact of gender and pre-menopausal state on short- and long-term outcomes in patients with septic shock. MATERIAL AND METHODS Cohort study of the Australasian Resuscitation in Sepsis Evaluation (ARISE) trial, an international randomized controlled trial comparing early goal-directed therapy (EGDT) to usual care in patients with early septic shock, conducted between October 2008 and April 2014. The primary exposure in this analysis was legal gender and the secondary exposure was pre-menopausal state defined by chronological age (≤ 50 years). RESULTS 641 (40.3%) of all 1591 ARISE trial participants in the intention-to-treat population were females and overall, 337 (21.2%) (146 females) patients were 50  years of age or younger. After risk-adjustment, we could not identify any survival benefit for female patients at day 90 in the younger (≤50 years) (adjusted Odds Ratio (aOR): 0.91 (0.46-1.89), p = .85) nor in the older (>50 years) age-group (aOR: 1.10 (0.81-1.49), p = .56). Similarly, there was no gender-difference in ICU, hospital, 1-year mortality nor quality of life measures. CONCLUSIONS This post-hoc analysis of a large multi-center trial in early septic shock has shown no short- or long-term survival effect for women overall as well as in the pre-menopausal age-group.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Lüthi, Nora

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0883-9441

Publisher:

Elsevier

Language:

English

Submitter:

Rebeka Gerber

Date Deposited:

22 Jan 2020 07:55

Last Modified:

22 Jan 2020 07:55

Publisher DOI:

10.1016/j.jcrc.2019.11.002

PubMed ID:

31739087

Uncontrolled Keywords:

Age Gender difference Intensive care Outcomes Pre-menopausal state Sepsis Septic shock Sex

BORIS DOI:

10.7892/boris.138405

URI:

https://boris.unibe.ch/id/eprint/138405

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