Comparing the lung cancer burden of ambient particulate matter using scenarios of air quality standards versus acceptable risk levels

Castro, Alberto; Götschi, Thomas; Achermann, Beat; Baltensperger, Urs; Buchmann, Brigitte; Felber Dietrich, Denise; Flückiger, Alexandre; Geiser, Marianne; Gälli Purghart, Brigitte; Gygax, Hans; Kutlar Joss, Meltem; Lüthi, Lara Milena; Probst-Hensch, Nicole; Strähl, Peter; Künzli, Nino (2020). Comparing the lung cancer burden of ambient particulate matter using scenarios of air quality standards versus acceptable risk levels. International journal of public health, 65(2), pp. 139-148. Springer 10.1007/s00038-019-01324-y

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Objectives Ambient particulate matter (PM) is regulated with science-based air quality standards, whereas carcinogens are regulated with a number of ‘‘acceptable’’ cases. Given that PM is also carcinogenic, we identify differences between approaches. Methods We assessed the lung cancer deaths for Switzerland attributable to exposure to PM up to 10 lm (PM10) and to five particle-bound carcinogens. For PM10, we used an epidemiological approach based on relative risks with four exposure scenarios compared to two counterfactual concentrations. For carcinogens, we used a toxicological approach based on unit risks with four exposure scenarios. Results The lung cancer burden using concentrations from 2010 was 10–14 times larger for PM10 than for the five carcinogens. However, the burden depends on the underlying exposure scenarios, counterfactual concentrations and number of carcinogens. All scenarios of the toxicological approach for five carcinogens result in a lower burden than the epidemiological approach for PM10. Conclusions Air quality standards—promoted so far by the WHO Air Quality Guidelines—provide a more appealing framework to guide health risk-oriented clean air policymaking than frameworks based on a number of ‘‘acceptable’’ cases.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Cell Biology

UniBE Contributor:

Geiser, Marianne

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1661-8556

Publisher:

Springer

Language:

English

Submitter:

Marianne Geiser Kamber

Date Deposited:

28 Jan 2020 15:55

Last Modified:

04 Mar 2020 01:33

Publisher DOI:

10.1007/s00038-019-01324-y

PubMed ID:

31912175

Uncontrolled Keywords:

Air pollution, Particulate matter, Lung cancer, Epidemiology, Toxicology, Health impact assessment, Carcinogens

BORIS DOI:

10.7892/boris.138627

URI:

https://boris.unibe.ch/id/eprint/138627

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