Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index

Agrawal, Rupesh; Ding, Jianbin; Sen, Parveen; Rousselot, Andres; Chan, Amy; Nivison-Smith, Lisa; Wei, Xin; Mahajan, Sarakshi; Kim, Ramasamy; Mishra, Chitaranjan; Agarwal, Manisha; Suh, Min Hee; Luthra, Saurabh; Munk, Marion; Cheung, Carol Y.; Gupta, Vishali (2020). Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index. Progress in retinal and eye research, 77, p. 100829. Elsevier 10.1016/j.preteyeres.2020.100829

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The choroid is one of the most vascularized structures of the human body and plays an irreplaceable role in nourishing photoreceptors. As such, choroidal dysfunction is implicated in a multitude of ocular diseases. Studying the choroid can lead to a better understanding of disease pathogenesis, progression and discovery of novel management strategies. However, current research has produced inconsistent findings, partly due to the physical inaccessibility of the choroid and the lack of reliable biomarkers. With the advancements in optical coherence tomography technology, our group has developed a novel quantitative imaging biomarker known as the choroidal vascularity index (CVI), defined as the ratio of vascular area to the total choroidal area. CVI is a potential tool in establishing early diagnoses, monitoring disease progression and prognosticating patients. CVI has been reported in existing literature as a robust marker in numerous retinal and choroidal diseases. In this review, we will discuss the current role of CVI with reference to existing literature, and make postulations about its potential and future applications.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Munk, Marion

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1873-1635

Publisher:

Elsevier

Language:

English

Submitter:

Marion Munk

Date Deposited:

21 Jan 2020 15:52

Last Modified:

15 Sep 2020 01:31

Publisher DOI:

10.1016/j.preteyeres.2020.100829

PubMed ID:

31927136

BORIS DOI:

10.7892/boris.138693

URI:

https://boris.unibe.ch/id/eprint/138693

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