Topical curcumin can inhibit deleterious effects of upper respiratory tract bacteria on human oropharyngeal cells in vitro: potential role for patients with cancer therapy induced mucositis?

Lüer, Sonja; Troller, Rolf; Jetter, Marion; Spaniol, Violeta; Aebi, Christoph (2011). Topical curcumin can inhibit deleterious effects of upper respiratory tract bacteria on human oropharyngeal cells in vitro: potential role for patients with cancer therapy induced mucositis? Supportive care in cancer, 19(6), pp. 799-806. Berlin: Springer-Verlag 10.1007/s00520-010-0894-x

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Curcumin exerts its anti-inflammatory activity via inhibition of nuclear factor κB. Oropharyngeal epithelia and residing bacteria closely interact in inflammation and infection. This in vitro model investigated the effects of curcumin on bacterial survival, adherence to, and invasion of upper respiratory tract epithelia, and studied its anti-inflammatory effect. We aimed to establish a model, which could offer insights into the host-pathogen interaction in cancer therapy induced mucositis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research

UniBE Contributor:

Lüer, Sonja Christina; Troller, Rolf; Jetter, Marion; Spaniol, Violeta and Aebi, Christoph

ISSN:

0941-4355

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

26 Jun 2018 15:41

Publisher DOI:

10.1007/s00520-010-0894-x

PubMed ID:

20467756

Web of Science ID:

000290029700010

BORIS DOI:

10.7892/boris.139

URI:

https://boris.unibe.ch/id/eprint/139 (FactScience: 196485)

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