Role of proteomic technologies in understanding risk of arterial thrombosis.

Polkinghorne, Victoria R; Standeven, Kristina F; Schroeder, Verena; Carter, Angela M (2009). Role of proteomic technologies in understanding risk of arterial thrombosis. Expert review of proteomics, 6(5), pp. 539-550. Taylor & Francis 10.1586/epr.09.75

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Arterial thrombosis is a pivotal event in the development of cardiovascular diseases. Plasma and cellular proteins have the potential to influence thrombus morphology and function. This review summarizes the latest studies to use proteomic technologies to characterize the cellular and plasma components involved in arterial thrombosis, with a view to understanding the pathogenesis and treatment of acute cardiovascular diseases. Proteomic approaches have been extensively used to profile the proteome of endothelial cells, leukocytes, vascular smooth muscle cells, platelets and plasma in the search for risk factors for cardiovascular disease; however, further work is required to validate the direct contribution of these proteins to arterial thrombosis.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Experimentelle Hämostase

UniBE Contributor:

Schröder, Verena

ISSN:

1744-8387

Publisher:

Taylor & Francis

Language:

English

Submitter:

Patrick Roger Flury

Date Deposited:

16 Jan 2020 09:56

Last Modified:

16 Jan 2020 09:56

Publisher DOI:

10.1586/epr.09.75

PubMed ID:

19811075

URI:

https://boris.unibe.ch/id/eprint/139070

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