Anatomical integrity within the inferior fronto-occipital fasciculus and semantic processing deficits in schizophrenia spectrum disorders.

Surbeck, Werner; Hänggi, Jürgen; Scholtes, Felix; Viher, Petra V.; Schmidt, André; Stegmayer, Katharina; Studerus, Erich; Lang, Udine E; Riecher-Rössler, Anita; Strik, Werner; Seifritz, Erich; Borgwardt, Stefan; Quednow, Boris B; Walther, Sebastian (2020). Anatomical integrity within the inferior fronto-occipital fasciculus and semantic processing deficits in schizophrenia spectrum disorders. Schizophrenia research, 218, pp. 267-275. Elsevier 10.1016/j.schres.2019.12.025

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The core symptoms of schizophrenia spectrum disorders (SSD) include abnormal semantic processing which may rely on the ventral language stream of the human brain. Thus, structural disruption of the ventral language stream may play an important role in semantic deficits observed in SSD patients. Therefore, we compared white matter tract integrity in SSD patients and healthy controls using diffusion tensor imaging combined with probabilistic fiber tractography. For the ventral language stream, we assessed the inferior fronto-occipital fasciculus [IFOF], inferior longitudinal fasciculus, and uncinate fasciculus. The arcuate fasciculus and corticospinal tract were used as control tracts. In SSD patients, the relationship between semantic processing impairments and tract integrity was analyzed separately. Three-dimensional tract reconstructions were performed in 45/44 SSD patients/controls ("Bern sample") and replicated in an independent sample of 24/24 SSD patients/controls ("Basel sample"). Multivariate analyses of fractional anisotropy, mean, axial, and radial diffusivity of the left IFOF showed significant differences between SSD patients and controls (p(FDR-corr) < 0.001, ηp2 = 0.23) in the Bern sample. Axial diffusivity (AD) of the left UF was inversely correlated with semantic impairments (r = -0.454, p(FDR-corr) = 0.035). In the Basel sample, significant group differences for the left IFOF were replicated (p < .01, ηp2 = 0.29), while the correlation between AD of the left IFOF and semantic processing decline (r = -0.376, p = .09) showed a statistical trend. No significant effects were found for the dorsal language stream. This is direct evidence for the importance of the integrity of the ventral language stream, in particular the left IFOF, in semantic processing deficits in SSD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Viher, Petra; Stegmayer, Katharina Deborah Lena; Strik, Werner and Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1573-2509

Publisher:

Elsevier

Language:

English

Submitter:

Sebastian Walther

Date Deposited:

04 Feb 2020 14:31

Last Modified:

18 Jun 2020 01:31

Publisher DOI:

10.1016/j.schres.2019.12.025

PubMed ID:

31948896

Uncontrolled Keywords:

Diffusion tensor imaging First episode psychosis Formal thought disorder Inferior frontooccipital fasciculus Schizophrenia Semantic impairment

BORIS DOI:

10.7892/boris.139280

URI:

https://boris.unibe.ch/id/eprint/139280

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