Acute hyperkalaemia in a captive Persian leopard ( Panthera pardus saxicolor ) immobilised with a ketamine-medetomidine combination

Dìez Bernal, Sabina; Hoby, Stefan; Levionnois, Olivier (2019). Acute hyperkalaemia in a captive Persian leopard ( Panthera pardus saxicolor ) immobilised with a ketamine-medetomidine combination. Veterinary Record Case Reports, 7(1), e000755. British Veterinary Association 10.1136/vetreccr-2018-000755

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A 12-year-old captive male Persian leopard (Panthera pardus saxicolor) required general anaesthesia for examination and treatment of a recurrent oral fistula. Medetomidine (0.065 mg/kg) and ketamine (3.6 mg/kg) administered intramuscularly by blowpipe darting effectively immobilised the animal that was maintained under general anaesthesia with inhaled isoflurane. In absence of clinical signs, acute hyperkalaemia (7.26 mmol/l) was incidentally recognised by the end of anaesthesia. Factors that might have played a role in hyperkalaemia development, such as the use of α2-adrenoceptor agonists, stress response, acidosis or dopamine administration, are discussed. Hyperkalaemia should be considered as a potential complication while anaesthetising large non-domestic felids.

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