Brain Derived Neurotrophic Factor alterations in patients with suicide risk: a Systematic Review and Meta-analysis

Singh, Sukhbir; Zuniga-Kennedy, Miranda S.; Mathur, Nandita; Kane, John M.; Malhotra, Anil K.; DeRosse, Pamela; Schoretsanitis, Georgios (21 January 2020). Brain Derived Neurotrophic Factor alterations in patients with suicide risk: a Systematic Review and Meta-analysis (Unpublished)

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Brain Derived Neurotrophic factor levels (BDNF) have been investigated in the context of hormonal and endocrine biomarkers of suicide risk. Cross-sectional studies have compared BDNF between patients with versus without suicide risk. Several studies have found lower BDNF levels in patients with suicide risk compared to patients without, while few studies did not report significant differences. This study aims to systematically review and meta-analyze data to examine differences for (plasma and serum) BDNF levels between patients with versus without suicide risk. The primary outcomes will be measured as the mean or standardized mean differences for peripheral serum or plasma blood concentrations of BDNF. Further analyses will encompass subgroup analyses and meta-regression assessing the impact of factors such as age, sex, body mass index, diagnosis, psychotropic medications, symptom severity and publication year. Results will be published in a peer-reviewed journal.

Item Type:

Working Paper

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy

UniBE Contributor:

Schoretsanitis, Georgios

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

Funders:

[UNSPECIFIED] No funding

Language:

English

Submitter:

Georgios Schoretsanitis

Date Deposited:

04 Feb 2020 14:39

Last Modified:

04 Feb 2020 14:39

Uncontrolled Keywords:

BDNF, suicidality, suicide risk, mood disorders

BORIS DOI:

10.7892/boris.139372

URI:

https://boris.unibe.ch/id/eprint/139372

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