A glance on the role of fibronectin in controlling cell response at biomaterial interface.

Parisi, Ludovica; Toffoli, Andrea; Ghezzi, Benedetta; Mozzoni, Beatrice; Lumetti, Simone; Macaluso, Guido M (2020). A glance on the role of fibronectin in controlling cell response at biomaterial interface. Japanese dental science review, 56(1), pp. 50-55. Elsevier 10.1016/j.jdsr.2019.11.002

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The bioactivity of biomaterials is closely related to cell response in contact with them. However, shortly after their insertion, materials are soon covered with proteins that constitute the biological fluids, and which render the direct surface recognition by cells almost impossible. The control of protein adsorption at the interface is therefore desirable. Extracellular matrix proteins are of particular interest in this sense, due to their well-known ability to modulate cell behavior. Particularly, fibronectin plays a leading role, being present in both healthy and injured tissues undergoing healing and regeneration. The aim of the present work is to give an overview on fibronectin and on its involvement in the control of cell behavior providing evidence of its pivotal role in the control of cell adhesion, spreading, migration, proliferation and differentiation. A deep insight into methods to enrich biomaterials surface with fibronectin will be then discussed, as well as new cues on the possibility to design tailored platforms able to specifically retain fibronectin from the surrounding extracellular milieu.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine

UniBE Contributor:

Parisi, Ludovica

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1882-7616

Publisher:

Elsevier

Language:

English

Submitter:

Renate Imhof-Etter

Date Deposited:

04 Feb 2020 09:54

Last Modified:

04 Feb 2020 09:54

Publisher DOI:

10.1016/j.jdsr.2019.11.002

PubMed ID:

31890058

Uncontrolled Keywords:

Biomaterials Bone regeneration Fibronectin Regenerative medicine Tissue engineering

BORIS DOI:

10.7892/boris.139408

URI:

https://boris.unibe.ch/id/eprint/139408

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