Inglin, R. A.; Brügger, L. E.; Candinas, D.; Harrison, B. S.; Eberli, D. (2019). Effect of oxygen-producing suture material on hypoxic colonic anastomoses in an experimental model. BJS open, 3(6), pp. 872-881. Wiley 10.1002/bjs5.50220
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Background
Anastomotic leak remains a significant cause of morbidity and mortality after colorectal surgery. Among multiple risk factors considered, hypoxia-ischaemia is considered to be a primary cause of intestinal anastomotic leakage. The aim of this experimental study was to assess safety, usability for surgical tasks, and efficacy of a newly developed oxygen-producing suture material in the healing of colonic anastomoses under critical conditions.
Methods
An oxygen-producing suture material was produced that is capable of releasing oxygen directly into the surrounding tissue. Off-the-shelf sutures loaded with calcium peroxide nano-crystals and covered with poly(d,l-lactide-co-glycolide) were assessed in vitro and in a rat model of hypoxic colonic anastomosis.
Results
In vitro assessment showed that these sutures can increase oxygen levels in a hypoxic environment. Potential oxygen byproducts did not seem to have a negative impact on the viability of intestinal cells. The use of oxygen-producing sutures in vivo resulted in increased tissue oxygen saturation, measured by visible light spectroscopy, and increased mechanical stability of the anastomosis.
Conclusion
Oxygen-producing suture material increased tissue oxygen saturation and mechanical stability of colonic anastomosis in a rat model.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine |
UniBE Contributor: |
Brügger, Lukas, Candinas, Daniel |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2474-9842 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Lilian Karin Smith-Wirth |
Date Deposited: |
05 Feb 2020 08:57 |
Last Modified: |
05 Dec 2022 15:36 |
Publisher DOI: |
10.1002/bjs5.50220 |
PubMed ID: |
31832595 |
BORIS DOI: |
10.7892/boris.139427 |
URI: |
https://boris.unibe.ch/id/eprint/139427 |
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