Effect of oxygen-producing suture material on hypoxic colonic anastomoses in an experimental model.

Inglin, R. A.; Brügger, L. E.; Candinas, D.; Harrison, B. S.; Eberli, D. (2019). Effect of oxygen-producing suture material on hypoxic colonic anastomoses in an experimental model. BJS open, 3(6), pp. 872-881. Wiley 10.1002/bjs5.50220

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Background Anastomotic leak remains a significant cause of morbidity and mortality after colorectal surgery. Among multiple risk factors considered, hypoxia-ischaemia is considered to be a primary cause of intestinal anastomotic leakage. The aim of this experimental study was to assess safety, usability for surgical tasks, and efficacy of a newly developed oxygen-producing suture material in the healing of colonic anastomoses under critical conditions. Methods An oxygen-producing suture material was produced that is capable of releasing oxygen directly into the surrounding tissue. Off-the-shelf sutures loaded with calcium peroxide nano-crystals and covered with poly(d,l-lactide-co-glycolide) were assessed in vitro and in a rat model of hypoxic colonic anastomosis. Results In vitro assessment showed that these sutures can increase oxygen levels in a hypoxic environment. Potential oxygen byproducts did not seem to have a negative impact on the viability of intestinal cells. The use of oxygen-producing sutures in vivo resulted in increased tissue oxygen saturation, measured by visible light spectroscopy, and increased mechanical stability of the anastomosis. Conclusion Oxygen-producing suture material increased tissue oxygen saturation and mechanical stability of colonic anastomosis in a rat model.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

Brügger, Lukas and Candinas, Daniel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2474-9842

Publisher:

Wiley

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

05 Feb 2020 08:57

Last Modified:

05 Feb 2020 08:57

Publisher DOI:

10.1002/bjs5.50220

PubMed ID:

31832595

BORIS DOI:

10.7892/boris.139427

URI:

https://boris.unibe.ch/id/eprint/139427

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