Impact of the early-life skin microbiota on the development of canine atopic dermatitis in a high-risk breed birth cohort.

Rodriguez-Campos, S.; Rostaher, A; Zwickl, L; Fischer, N; Brodard, I.; Vidal, S.; Brandt, B W; Favrot, C; Perreten, V. (2020). Impact of the early-life skin microbiota on the development of canine atopic dermatitis in a high-risk breed birth cohort. Scientific reports, 10(1), p. 1044. Springer Nature 10.1038/s41598-020-57798-x

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Canine atopic dermatitis (CAD) is a prevalent inflammatory skin disease of dogs worldwide. Certain breeds such as the West Highland White Terriers (WHWT) are predisposed to suffer from CAD. Microbial dysbiosis is known to play a significant role in the pathogenesis of the disease, which is similar to its human counterpart, atopic dermatitis (AD). To date, no large cohort-study has been conducted in a predisposed dog breed to study the impact of the early-life microbiota on the development of CAD, as well as the possible implication of factors such as hygiene and access to the outdoors. In this study skin samples of 143 WHWT, including 109 puppies up to three weeks old and 34 parent dogs, from 17 breeders, were subjected to 16S rRNA gene and ITS2 amplicon sequencing to disclose the bacterial and fungal oral and skin microbiota, respectively. The oral samples served as a control group to confirm differences between haired and mucosal surfaces. The cutaneous microbiota differed between sample sites and age of the dogs. The season of sampling, geographical origin as well as hygiene status of the household and the access to the outdoors shaped the skin microbiota of the puppies significantly. However, we found that the individual early-life microbiota did not predispose for the later development of CAD.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology > Molecular Bacterial Epidemiology and Infectiology
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

UniBE Contributor:

Rodriguez, Sabrina; Brodard, Isabelle; Vidal Lopez, Sara and Perreten, Vincent

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

2045-2322

Publisher:

Springer Nature

Language:

English

Submitter:

Vincent Perreten

Date Deposited:

04 Feb 2020 12:48

Last Modified:

09 Feb 2020 02:46

Publisher DOI:

10.1038/s41598-020-57798-x

PubMed ID:

31974513

BORIS DOI:

10.7892/boris.139619

URI:

https://boris.unibe.ch/id/eprint/139619

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