PFM-Like Enzymes Are a Novel Family of Subclass B2 Metallo-β-Lactamases from Pseudomonas synxantha Belonging to the Pseudomonas fluorescens Complex.

Poirel, Laurent; Palmieri, Mattia; Brilhante, Michael; Masseron, Amandine; Perreten, Vincent; Nordmann, Patrice (2020). PFM-Like Enzymes Are a Novel Family of Subclass B2 Metallo-β-Lactamases from Pseudomonas synxantha Belonging to the Pseudomonas fluorescens Complex. Antimicrobial agents and chemotherapy, 64(2) American Society for Microbiology 10.1128/AAC.01700-19

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A carbapenem-resistant Pseudomonas synxantha isolate recovered from chicken meat produced the novel carbapenemase PFM-1. That subclass B2 metallo-β-lactamase shared 71% amino acid identity with β-lactamase Sfh-1 from Serratia fonticola The blaPFM-1 gene was chromosomally located and likely acquired. Variants of PFM-1 sharing 90% to 92% amino acid identity were identified in bacterial species belonging to the Pseudomonas fluorescens complex, including Pseudomonas libanensis (PFM-2) and Pseudomonas fluorescens (PFM-3), highlighting that these species constitute reservoirs of PFM-like encoding genes.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology > Molecular Bacterial Epidemiology and Infectiology
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Quinta Brilhante, Michael and Perreten, Vincent

Subjects:

500 Science
500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Vincent Perreten

Date Deposited:

04 Feb 2020 12:43

Last Modified:

04 Feb 2020 12:52

Publisher DOI:

10.1128/AAC.01700-19

PubMed ID:

31685461

Uncontrolled Keywords:

PFM-1 Pseudomonas fluorescens metallo-beta-lactamase

BORIS DOI:

10.7892/boris.139620

URI:

https://boris.unibe.ch/id/eprint/139620

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