In vivo relationship between near-infrared spectroscopy-detected lipid-rich plaques and morphological plaque characteristics by optical coherence tomography and intravascular ultrasound: a multimodality intravascular imaging study.

Zanchin, Christian; Ueki, Yasushi; Losdat, Sylvain; Fahrni, Gregor; Daemen, Joost; Ondracek, Anna S; Häner, Jonas D.; Stortecky, Stefan; Otsuka, Tatsuhiko; Siontis, George C.M.; Rigamonti, Fabio; Radu, Maria; Spirk, David; Kaiser, Christoph; Engstrom, Thomas; Lang, Irene; Koskinas, Konstantinos C.; Räber, Lorenz (2020). In vivo relationship between near-infrared spectroscopy-detected lipid-rich plaques and morphological plaque characteristics by optical coherence tomography and intravascular ultrasound: a multimodality intravascular imaging study. (In Press). European heart journal - cardiovascular imaging Oxford University Press 10.1093/ehjci/jez318

[img] Text
Zanchin EurHeartJCardiovascImaging 2020_epub.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

AIMS

We assessed morphological features of near-infrared spectroscopy (NIRS)-detected lipid-rich plaques (LRPs) by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS).

METHODS AND RESULTS

IVUS-NIRS and OCT were performed in the two non-infarct-related arteries (non-IRAs) in patients undergoing percutaneous coronary intervention for treatment of an acute coronary syndrome. A lesion was defined as the 4 mm segment with the maximum amount of lipid core burden index (maxLCBI4mm) of each LRP detected by NIRS. We divided the lesions into three groups based on the maxLCBI4mm value: <250, 250-399, and ≥400. OCT analysis and IVUS analysis were performed blinded for NIRS. We measured fibrous cap thickness (FCT) by using a semi-automated method. A total of 104 patients underwent multimodality imaging of 209 non-IRAs. NIRS detected 299 LRPs. Of those, 41% showed a maxLCBI4mm <250, 39% a maxLCBI4mm 251-399, and 19% a maxLCBI4mm ≥400. LRPs with a maxLCBI4mm ≥400, as compared with LRPs with a maxLCBI4mm 250-399 and <250, were more frequently thin-cap fibroatheroma (TCFA) (42.1% vs. 5.1% and 0.8%; P < 0.001) with a smaller minimum FCT (80 μm vs. 110 μm and 120 μm; P < 0.001); a higher IVUS-derived percent atheroma volume (53% vs. 53% and 44%; P < 0.001) and a higher remodelling index (1.08 vs. 1.02 and 1.01; P < 0.001). MaxLCBI4mm correlated with OCT-derived FCT (r = 0.404; P < 0.001) and was the best predictor for TCFA with an optimal cut-off value of 401 (area under the curve = 0.882; P < 0.001).

CONCLUSION

LRPs with increasing maxLCBI4mm exhibit OCT and IVUS features of presumed plaque vulnerability including TCFA morphology, increased plaque burden, and positive remodelling.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Zanchin, Christian; Ueki, Yasushi; Losdat, Sylvain Pierre; Häner, Jonas; Stortecky, Stefan; Otsuka, Tatsuhiko; Siontis, Georgios; Spirk, David; Koskinas, Konstantinos and Räber, Lorenz

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2047-2412

Publisher:

Oxford University Press

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

11 Feb 2020 10:42

Last Modified:

14 Oct 2020 21:43

Publisher DOI:

10.1093/ehjci/jez318

PubMed ID:

31990323

Uncontrolled Keywords:

Coronary artery disease Intravascular imaging Lipid-rich plaque Plaque vulnerability maxLCBI4mm

BORIS DOI:

10.7892/boris.139773

URI:

https://boris.unibe.ch/id/eprint/139773

Actions (login required)

Edit item Edit item
Provide Feedback