Savović, J; Jones, He; Altman, Dg; Harris, Rj; Jűni, P; Pildal, J; Als-Nielsen, B; Balk, Em; Gluud, C; Gluud, Ll; Ioannidis, Jpa; Schulz, Kf; Beynon, R; Welton, N; Wood, L; Moher, D; Deeks, Jj; Sterne, Jac (2012). Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials: combined analysis of meta-epidemiological studies. Health technology assessment, 16(35), pp. 1-82. Southampton, UK: National Coordinating Centre for Health Technology Assessment 10.3310/hta16350
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The design of randomised controlled trials (RCTs) should incorporate characteristics (such as concealment of randomised allocation and blinding of participants and personnel) that avoid biases resulting from lack of comparability of the intervention and control groups. Empirical evidence suggests that the absence of such characteristics leads to biased intervention effect estimates, but the findings of different studies are not consistent.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Jüni, Peter |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1366-5278 |
Publisher: |
National Coordinating Centre for Health Technology Assessment |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:35 |
Last Modified: |
05 Dec 2022 14:11 |
Publisher DOI: |
10.3310/hta16350 |
PubMed ID: |
22989478 |
Web of Science ID: |
000311662000001 |
BORIS DOI: |
10.7892/boris.13989 |
URI: |
https://boris.unibe.ch/id/eprint/13989 (FactScience: 220711) |
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