Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials: combined analysis of meta-epidemiological studies

Savović, J; Jones, He; Altman, Dg; Harris, Rj; Jűni, P; Pildal, J; Als-Nielsen, B; Balk, Em; Gluud, C; Gluud, Ll; Ioannidis, Jpa; Schulz, Kf; Beynon, R; Welton, N; Wood, L; Moher, D; Deeks, Jj; Sterne, Jac (2012). Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials: combined analysis of meta-epidemiological studies. Health technology assessment, 16(35), pp. 1-82. Southampton, UK: National Coordinating Centre for Health Technology Assessment 10.3310/hta16350

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The design of randomised controlled trials (RCTs) should incorporate characteristics (such as concealment of randomised allocation and blinding of participants and personnel) that avoid biases resulting from lack of comparability of the intervention and control groups. Empirical evidence suggests that the absence of such characteristics leads to biased intervention effect estimates, but the findings of different studies are not consistent.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Jüni, Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1366-5278

Publisher:

National Coordinating Centre for Health Technology Assessment

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:35

Last Modified:

23 Oct 2019 05:52

Publisher DOI:

10.3310/hta16350

PubMed ID:

22989478

Web of Science ID:

000311662000001

BORIS DOI:

10.7892/boris.13989

URI:

https://boris.unibe.ch/id/eprint/13989 (FactScience: 220711)

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