The vascular-disrupting agent combretastatin impairs splitting and sprouting forms of physiological angiogenesis

Hussain, Arif; Steimle, Manuel; Hoppeler, Hans; Baum, Oliver; Egginton, Stuart (2012). The vascular-disrupting agent combretastatin impairs splitting and sprouting forms of physiological angiogenesis. Microcirculation, 19(4), pp. 296-305. Malden, Mass.: Wiley-Blackwell 10.1111/j.1549-8719.2012.00160.x

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Vascular-disrupting agents like combretastatin (CA-4-P), used to attenuate tumor blood flow in vivo, exert anti-mitotic and anti-migratory effects on endothelial cells in vitro. We tested whether anti-vascular or anti-angiogenic effects of CA-4-P are evident with physiological angiogenesis in skeletal muscle (EDL) due to sustained hyperemia (intraluminal splitting) and chronic muscle overload (abluminal sprouting).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy

UniBE Contributor:

Hoppeler, Hans-Heinrich and Baum, Oliver

ISSN:

1073-9688

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:35

Last Modified:

17 Mar 2015 21:25

Publisher DOI:

10.1111/j.1549-8719.2012.00160.x

PubMed ID:

22236138

Web of Science ID:

000303159500002

URI:

https://boris.unibe.ch/id/eprint/14058 (FactScience: 220861)

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