MET targeting: time for a rematch.

Koch, Jonas P.; Aebersold, Daniel M.; Zimmer, Yitzhak; Medová, Michaela (2020). MET targeting: time for a rematch. Oncogene, 39(14), pp. 2845-2862. Springer Nature 10.1038/s41388-020-1193-8

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MET, the receptor tyrosine kinase (RTK) for hepatocyte growth factor, is a proto-oncogene involved in embryonic development and throughout life in homeostasis and tissue regeneration. Deregulation of MET signaling has been reported in numerous malignancies, prompting great interest in MET targeting for cancer therapy. The present review offers a summary of the biology of MET and its known functions in normal physiology and carcinogenesis, followed by an overview of the most relevant MET-targeting strategies and corresponding clinical trials, highlighting both past setbacks and promising future prospects. By placing their efforts on a more precise stratification strategy through the genetic analysis of tumors, modern trials such as the NCI-MATCH trial could revive the past enthusiasm for MET-targeted therapy.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radio-Onkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radio-Onkologie

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Koch, Jonas Paul; Aebersold, Daniel; Zimmer, Yitzhak and Medova, Michaela

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1476-5594

Publisher:

Springer Nature

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

24 Feb 2020 14:25

Last Modified:

05 Apr 2020 01:37

Publisher DOI:

10.1038/s41388-020-1193-8

PubMed ID:

32034310

BORIS DOI:

10.7892/boris.140589

URI:

https://boris.unibe.ch/id/eprint/140589

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