Canine sterile neutrophilic dermatosis (resembling Sweet's syndrome) with severe extracutaneous manifestations.

Hammes, K.; Vannini, I.; Nitzl, D.; B. Veiga, I.; Wiener, D. J.; Wenger-Riggenbach, B. (2019). Canine sterile neutrophilic dermatosis (resembling Sweet's syndrome) with severe extracutaneous manifestations. Schweizer Archiv für Tierheilkunde, 161(4), pp. 231-238. Gesellschaft Schweizer Tierärztinnen und Tierärzte 10.17236/sat00203

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INTRODUCTION Sterile neutrophilic dermatosis is a rare disease in dogs, similar to Sweet's syndrome in humans. This case report describes the treatment of a 2-year old Bearded Collie that was presented with a 3-week history of fever, hind-limb weakness, peripheral lymphadenomegaly and leucocytosis. Blood tests revealed severe leukocytosis, renal azotaemia, elevated liver enzymes and bilirubinaemia. Skin lesions started to appear in week four. Histology revealed a sterile neutrophilic dermatitis resembling Sweet's syndrome. The dog displayed extracutaneous manifestations, including fever, polyarthritis, a severe leukemoid reaction, anaemia, hepatopathy and nephropathy. Issues regarding the use of criteria for the diagnosis of Sweet's syndrome in humans that are used for dogs with sterile neutrophilic dermatosis, are discussed in this case report. The condition resolved with dexamethasone and mycophenolate mofetil as a novel steroid-sparing therapy. Three months later the dog relapsed, which rapidly responded to short-term dexamethasone treatment and temporarily increased mycophenolate mofetil dosage.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Berenguer Veiga, Inês Margarida and Wiener, Dominique Judith

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1664-2848

Publisher:

Gesellschaft Schweizer Tierärztinnen und Tierärzte

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

11 Mar 2020 14:08

Last Modified:

11 Mar 2020 14:08

Publisher DOI:

10.17236/sat00203

PubMed ID:

30942190

Uncontrolled Keywords:

Autoimmun-vermittelt Hund autoimmune mediata autoimmune mediated cane chien dermatose neutrophilique stérile dermatosi neutrofila sterile dog extracutaneous manifestations extrakutane Manifestationen manifestations extracutanées manifestazioni extracutanee médiation auto-immune sterile neutrophile Dermatose sterile neutrophilic dermatosis

BORIS DOI:

10.7892/boris.140647

URI:

https://boris.unibe.ch/id/eprint/140647

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