Morphofunctional adaptations of the olfactory mucosa in postnatally developing rabbits

Kavoi, Boniface M; Makanya, Andrew N; Plendl, Johanna; Johanna, Plendl; Kiama, Stephen G (2012). Morphofunctional adaptations of the olfactory mucosa in postnatally developing rabbits. Anatomical record: advances in integrative anatomy and evolutionary biology, 295(8), pp. 1352-63. Hoboken, N.J.: John Wiley & Sons, Inc. 10.1002/ar.22520

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Rabbits are born blind and deaf and receive unusually limited maternal care. Consequently, their suckling young heavily rely on the olfactory cue for nipple attachment. However, the postnatal morphofunctional adaptations of olfactory mucosa (OM) are not fully elucidated. To clarify on the extent and the pattern of refinement of the OM following birth in the rabbit, morphologic and morphometric analysis of the mucosa were done at neonatal (0-1 days), suckling (2 weeks), weanling (4 weeks), and adult (6-8 months) stages of postnatal development. In all the age groups, the basic components of the OM were present. However, proliferative activity of cells of the mucosal epithelium decreased with increasing age as revealed by Ki-67 immunostaining. Diameters of axon bundles, packing densities of olfactory cells, and cilia numbers per olfactory cell knob increased progressively with age being 5.5, 2.1, and 2.6 times, respectively, in the adult as compared with the neonate. Volume fraction values for the bundles increased by 5.3% from birth to suckling age and by 7.4% from weaning to adulthood and the bundle cores were infiltrated with blood capillaries in all ages except in the adult where such vessels were lacking. The pattern of cilia projection from olfactory cell knobs also showed age-related variations, that is, arose as a tuft from the tips of the knobs in neonates and sucklings and in a radial pattern from the knob bases in weanlings and adults. These morphological changes may be attributed to the high olfactory functional demand associated with postnatal development in the rabbit.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Makanya, Andrew

ISSN:

1932-8486

Publisher:

John Wiley & Sons, Inc.

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:35

Last Modified:

17 Mar 2015 21:25

Publisher DOI:

10.1002/ar.22520

PubMed ID:

22707244

Web of Science ID:

000306066700012

URI:

https://boris.unibe.ch/id/eprint/14066 (FactScience: 220870)

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