Preprocessing, analysis and quantification in single-voxel magnetic resonance spectroscopy: experts' consensus recommendations.

Near, Jamie; Harris, Ashley D; Juchem, Christoph; Kreis, Roland; Marjańska, Małgorzata; Öz, Gülin; Slotboom, Johannes; Wilson, Martin; Gasparovic, Charles (2020). Preprocessing, analysis and quantification in single-voxel magnetic resonance spectroscopy: experts' consensus recommendations. (In Press). NMR in biomedicine(e4257), e4257. Wiley 10.1002/nbm.4257

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Once an MRS dataset has been acquired, several important steps must be taken to obtain the desired metabolite concentration measures. First, the data must be preprocessed to prepare them for analysis. Next, the intensity of the metabolite signal(s) of interest must be estimated. Finally, the measured metabolite signal intensities must be converted into scaled concentration units employing a quantitative reference signal to allow meaningful interpretation. In this paper, we review these three main steps in the post-acquisition workflow of a single-voxel MRS experiment (preprocessing, analysis and quantification) and provide recommendations for best practices at each step.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Abt. Magnetresonanz-Spektroskopie und Methodologie, AMSM

UniBE Contributor:

Kreis, Roland and Slotboom, Johannes

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1099-1492

Publisher:

Wiley

Funders:

[42] Schweizerischer Nationalfonds

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

04 Mar 2020 17:01

Last Modified:

14 Jul 2020 14:11

Publisher DOI:

10.1002/nbm.4257

PubMed ID:

32084297

Uncontrolled Keywords:

MRS analysis preprocessing processing quantification quantitation water referencing

BORIS DOI:

10.7892/boris.140817

URI:

https://boris.unibe.ch/id/eprint/140817

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