Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells

Koch, A; Völzke, A; Wünsche, C; Meyer zu Heringdorf, D; Huwiler, A; Pfeilschifter, J (2012). Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells. British journal of pharmacology, 166(3), pp. 1018-32. Oxford: Wiley-Blackwell 10.1111/j.1476-5381.2012.01824.x

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PPARγ agonists [thiazolidinediones (TZDs)] are known to exert anti-fibrotic effects in the kidney. In addition, we previously demonstrated that sphingosine kinase 1 (SK-1) and intracellular sphingosine-1-phosphate (S1P), by reducing the expression of connective tissue growth factor (CTGF), have a protective role in the fibrotic process.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Huwiler, Andrea

ISSN:

0007-1188

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:35

Last Modified:

17 Mar 2015 21:25

Publisher DOI:

10.1111/j.1476-5381.2012.01824.x

PubMed ID:

22221312

Web of Science ID:

000303923000017

URI:

https://boris.unibe.ch/id/eprint/14088 (FactScience: 220895)

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