Development of a standardized definition of pulmonary embolism-related death: a cross-sectional survey of international thrombosis experts.

Tritschler, Tobias; Kraaijpoel, Noémie; Langlois, Nicole; Girard, Philippe; Schulman, Sam; Büller, Harry R; Segers, Annelise; Righini, Marc; Le Gal, Grégoire (2020). Development of a standardized definition of pulmonary embolism-related death: a cross-sectional survey of international thrombosis experts. Journal of thrombosis and haemostasis, 18(6), pp. 1415-1420. Wiley-Blackwell 10.1111/jth.14775

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INTRODUCTION Pulmonary embolism (PE)-related death is often part of the primary outcome in venous thromboembolism (VTE) studies. The Scientific and Standardization Committee (SSC) of the International Society on Thrombosis and Haemostasis developed a definition for PE-related death and classification of the cause of death. The present survey evaluated a preliminary version of this definition and classification. METHODS Sixty-nine VTE experts from 9 countries were invited for a cross-sectional online survey on January 15th , 2019, including multiple-choice and open-ended questions on a seven-subcategory classification of the cause of death. Descriptive statistics were used to describe the results; qualitative comments were summarized. RESULTS Forty of 69 (58%) invitees completed the survey. All respondents agreed that guidance on classification of the cause of death in VTE studies is required. There was high agreement on the proposal (median overall score, 6; interquartile range, 6-7; scale from 1 [poor] to 7 [excellent]). All respondents approved the wording and content of the seven subcategories, except for 1 disagreeing vote for 2 subcategories (A3: 'PE is not objectively confirmed, but is most likely the main cause of death', and C1: 'Another cause of death is more likely than PE but has not been objectively confirmed'). Suggestions for improvement mainly concerned the extensiveness of the criteria and clinical situations described to define the cause of death. CONCLUSION Acceptance of the proposal was excellent. Suggestions for improvement were incorporated in the SSC communication on the definition of PE-related death and classification of the cause of death in VTE studies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Tritschler, Tobias

ISSN:

1538-7836

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Christine Baumgartner

Date Deposited:

10 Mar 2020 14:44

Last Modified:

06 Jun 2020 01:32

Publisher DOI:

10.1111/jth.14775

PubMed ID:

32073218

Uncontrolled Keywords:

Cause of Death Classification Mortality Pulmonary Embolism Venous thromboembolism

BORIS DOI:

10.7892/boris.140953

URI:

https://boris.unibe.ch/id/eprint/140953

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