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[ (2012) -455.8 (Heine) -457.1 (et) -459.6 (al\056) -457.9 (This) -462.1 (is) -449.1 (a) -8.8 (n) -456 (open\055access) -460.3 (arti) -10.9 (cle) -458 (distributed) -467.6 (under) -454.9 (the) -460.4 (terms) -462.4 (of) -457.7 (the) -452.3 (Cre) -9.5 (ative) -451.4 (Comm) -11.8 (ons) -452.1 (Attrib) -11.5 (ution) -456.6 (License\054) -465 (which) -464.6 (permits) ] TJ
-6.8368 -1.1463 TD
[ (unrestricted) -342.9 (use\054) -336.8 (distri) -11.2 (bution\054) -335.2 (and) -333.7 (reprod) -15.4 (uction) -334.8 (in) -332.7 (any) -338.3 (medium) -11.1 (\054) -328.5 (provide) -11.5 (d) -332.2 (the) -338.5 (original) -341.7 (author) -339.9 (and) -333.7 (source) -337.5 (are) -341.2 (credited\056) ] TJ
/F2af2a85ee-2e33-4573-b3c1-9892d2898e5c 1 Tf
0 -1.7885 TD
(Funding\072) Tj
/F3 1 Tf
4.7313 0 TD
[ (This) -453.9 (work) -455.4 (was) -451.9 (supported) -460.9 (by) -447.7 (the) -452.3 (Bundes) -11.7 (ministerium) -456.1 (fu) ] TJ
23.868 0.0163 TD
(\250) Tj
0.4309 -0.0163 TD
[ (r) -450.3 (Bildung) -455.7 (und) -447.7 (Forschung) -462.9 (\050TOMCAT\054) -458.9 (grant) -451 (number) -457.4 (01EZ0824\073) -455 (http\072\057\057ww) -16.6 (w\056bmbf\056de\057\051) -459.8 (and) ] TJ
-29.0302 -1.1381 TD
[ (Landesexzelle) -13.7 (nzinitiative) -258 (Hamburg) -267.7 (\050State) -259.6 (Excellence) -258.5 (Initiati) -11 (ve\054) -251.9 (Nanote) -9.1 (chnology) -256.5 (in) -259.6 (Medicine) -260.1 (\055) -258.9 (NAME\051\056) -258.8 (The) -252.8 (fund) -10.4 (ers) -254.4 (had) -252.4 (no) -261.8 (role) -258.7 (in) -251.4 (study) -259 (design\054) -260.1 (data) ] TJ
61.7836 0 TD
[ (collection) -263.1 (and) ] TJ
-61.7836 -1.1462 TD
[ (analysis\054) -338.2 (deci) -9.9 (sion) -336.9 (to) -334.4 (publish\054) -341.2 (or) -337.3 (preparation) -339.7 (of) -335.8 (the) -338.5 (manuscri) -11.9 (pt\056) ] TJ
/F2af2a85ee-2e33-4573-b3c1-9892d2898e5c 1 Tf
0 -1.7803 TD
[ (Competing) -342.6 (Interest) -12.1 (s\072) ] TJ
/F3 1 Tf
10.4626 0 TD
[ (The) -334.1 (authors) -343.3 (have) -331.3 (decl) -9.9 (ared) -332 (that) -343.5 (no) -334.9 (competing) -338.4 (intere) -11 (sts) -332.2 (exist\056) ] TJ
-10.4626 -1.7885 TD
[ (\052) -331.9 (E\055mail\072) -336.5 (ma\056h) -9.2 (eine\100uke\056uni) -12.2 (\055hamburg\056de) ] TJ
/F2af2a85ee-2e33-4573-b3c1-9892d2898e5c 1 Tf
9.9626 0 0 9.9626 58.0535 221.7259 Tm
[ (In) -6.2 (troduction) ] TJ
/F6 1 Tf
8.9663 0 0 8.9663 67.011 204.8881 Tm
[ (Detection) -135.2 (of) -127.8 (cancer) -128 (cells) -133.3 (and) -124.9 (more) -128.9 (specifically) -133.2 (the) -132 (characterisation) ] TJ
-0.999 -1.1887 TD
[ (of) -254.3 (metastatic) -254.1 (cancer) -254.4 (cells) -253.4 (in) -249.6 (a) -252.8 (non\055invasive) -252 (way) -255.9 (is) -251.6 (a) -246.5 (primary) -257.8 (aim) -250.4 (of) ] TJ
0 -1.195 TD
[ (molecular) -126.4 (imaging\056) -123.2 (Several) -122.5 (approaches) -129.7 (such) -117.4 (as) -122.1 (Magnetic) -127.4 (Resonance) ] TJ
0 -1.1887 TD
[ (Imaging) -168.1 (\050MRI\051\054) -170.4 (Positron) -165.4 (Emission) -169.6 (Tomography) -167.4 (\050PET\051\054) -163.7 (and) -169.2 (Optical) ] TJ
T*
[ (Imaging) -218.7 (techniques) -218.4 (were) -215.8 (invented) -218.5 (for) -219.1 (this) -213.6 (purpose\056) -223.1 (All) -210.7 (applications) ] TJ
T*
[ (require) -206.1 (specific) -209.4 (probes) -202.8 (against) -206.9 (antigens) -206.4 (that) -202 (are) -204.2 (highly) -210.1 (expressed) -205.5 (on) ] TJ
T*
[ (the) -264.8 (surface) -266.5 (of) -266.9 (human) -265.1 (cancer) -260.8 (cells\056) -269 (For) -259.5 (promising) -262.4 (probes\054) -268.9 (a) -265.5 (specific) ] TJ
T*
[ (tumour) -638.6 (uptake) ] TJ
/F7 1 Tf
6.9678 0 TD
[ (in) -630.2 (vivo) ] TJ
/F6 1 Tf
3.2437 0 TD
[ (has) -634.4 (been) -635.7 (demonstrated) -639 (after) -635.9 (systemic) ] TJ
-10.2115 -1.1887 TD
[ (administration) -378.8 (via) -373.1 (intravenous) -375.1 (application) -379.2 (in) -369.8 (appropriate) -375.1 (animal) ] TJ
T*
[ (models) -235.5 (\1331\135\056) -226.9 (The) -231.8 (overall) -235 (probe) -232.3 (biodistribution) -230.3 (and) -232.4 (more) -230.1 (specifically) ] TJ
T*
[ (the) -359.6 (histological) -359.8 (distribution) -362.3 (of) -355.5 (the) -359.6 (bound) -361.7 (probe) -358.8 (within) -353.2 (the) -359.6 (tested) ] TJ
T*
[ (tumour) -202.3 (should) -202.2 (be) -206.4 (analysed) -200.5 (in) -199 (these) -202.9 (models\056) ] TJ
0.999 -1.2077 TD
[ (The) -585.9 (epithelial) -580.5 (cell) -580.1 (adhesion) -584 (molecule) -578.3 (\050EpCAM\073) -583.7 (CD326\051) -582.9 (is) ] TJ
-0.999 -1.1887 TD
[ (membranous) -470.3 (38\055kDa) -473.2 (glycoprotein) -471.5 (which) -467.2 (is) -466.6 (highly) -469.4 (expressed) -471 (in) ] TJ
28.6681 17.5208 TD
[ (cancer) -324 (tissue) -320.8 (of) -323.8 (different) -322.4 (entities) -322.4 (and) -320.9 (to) -321.8 (a) -322.4 (lower) -324.7 (extent) -322.3 (by) -318.2 (normal) ] TJ
0 -1.1887 TD
[ (epithelium) -585.2 (\1332\0543\135\056) -583.3 (Elevated) -584.2 (EpCAM) -579.5 (expression) -583.3 (was) -583.2 (confirmed) ] TJ
T*
[ (amongst) -716.8 (other) -715.9 (tumour) -714.4 (entities) -714.4 (in) -711.2 (breast\054) -719.7 (pancreatic\054) -713.7 (colon\054) ] TJ
T*
[ (prostate) -381 (and) -377.8 (lung) -379.1 (cancer) -380.9 (\1334\0545\0546\0547\135\056) -373.2 (The) -377.2 (impact) -378.1 (of) -380.7 (high) -376.1 (EpCAM) ] TJ
T*
[ (expression) -425.2 (on) -429.6 (patient\222s) -422.6 (survival) -431.7 (is) -422.3 (still) -424.7 (an) -423.6 (ongoing) -425.5 (debate\056) -428 (High) ] TJ
T*
[ (EpCAM) -472.1 (expression) -469.5 (was) -469.4 (associated) -468.4 (with) -470.3 (poor) -468.1 (survival) -469.7 (rates) -471.7 (for) ] TJ
T*
[ (breast\054) -258.1 (gall) -248.9 (bladder) -257.7 (and) -251.4 (squamous) -259.2 (cell) -251.3 (carcinoma) -252.1 (of) -254.3 (the) -252.1 (esophagus) ] TJ
T*
[ (whereas) -780.6 (better) -777.1 (survival) -779.5 (rates) -781.5 (were) -778.5 (reported) -777.9 (for) -775.5 (renal) -780.9 (cell) ] TJ
T*
[ (carcinoma) -353.3 (and) -346.2 (pancreatic) -350.4 (cancer) -349.3 (\1338\0549\05410\05411\05412\135\056) -348.7 (The) -351.9 (correlation) ] TJ
T*
[ (of) -304.9 (EpCAM) -307.7 (expression) -311.4 (and) -301.9 (clinical) -311.4 (outcome) -304 (therefore) -308 (depends) -312.3 (on) ] TJ
T*
[ (the) -334.3 (cancer) -336.6 (entity\056) ] TJ
0.999 -1.214 TD
[ (EpCAM) -396.2 (was) -393.5 (the) -391.2 (first) -395.1 (target) -393.4 (for) -396.1 (monoclonal) -397 (antibody) -394.7 (therapy) ] TJ
-0.999 -1.1887 TD
[ (against) -365 (human) -359.9 (cancer\056) -364.8 (Furthermore\054) -366.9 (the) -359.6 (first) -363.5 (successful) -365.6 (antibody) ] TJ
T*
[ (based) -295.3 (therapy) -301 (judged) -294.6 (by) -292.9 (of) -292.2 (overall) -298.3 (survival) -292.6 (was) -298.7 (achieved) -290.9 (using) -300.6 (an) ] TJ
T*
[ (anti) -445.3 (EpCAM) -440.4 (antibody) -445.3 (\13313\05414\135\056) -449.5 (Several) -445 (studies) -445.7 (for) -440.4 (non\055invasive) ] TJ
T*
[ (monitoring) -666 (of) -665.3 (cancer) -665.4 (cells) -664.4 (in) -660.6 (xenograft) -668.5 (mouse) -664.2 (models) -665.5 (with) ] TJ
ET
58.054 749.027 496.176 -0.51 re
f
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146.956 754.767 l
f
148.731 757.736 m
149.261 755.92 l
149.356 755.592 149.421 755.281 149.484 754.968 c
149.509 754.968 l
149.572 755.288 149.636 755.583 149.723 755.92 c
150.227 757.736 l
151.509 757.736 l
150.052 753.825 l
148.837 753.825 l
147.413 757.736 l
148.731 757.736 l
f
154.093 755.672 m
153.452 755.672 152.956 755.519 152.956 755.056 c
152.956 754.745 153.164 754.592 153.436 754.592 c
153.732 754.592 153.988 754.791 154.068 755.039 c
154.085 755.103 154.093 755.176 154.093 755.247 c
154.093 755.672 l
h
155.268 754.767 m
155.268 754.4 155.284 754.039 155.332 753.825 c
154.236 753.825 l
154.164 754.216 l
154.139 754.216 l
153.884 753.905 153.484 753.736 153.02 753.736 c
152.227 753.736 151.757 754.312 151.757 754.935 c
151.757 755.953 152.669 756.433 154.052 756.433 c
154.052 756.48 l
154.052 756.687 153.94 756.984 153.341 756.984 c
152.94 756.984 152.516 756.849 152.261 756.697 c
152.036 757.472 l
152.307 757.623 152.845 757.825 153.555 757.825 c
154.86 757.825 155.268 757.056 155.268 756.136 c
155.268 754.767 l
f
156.236 757.737 1.216 -3.912 re
156.837 758.216 m
156.452 758.216 156.204 758.489 156.204 758.825 c
156.204 759.167 156.46 759.432 156.852 759.432 c
157.245 759.432 157.484 759.167 157.492 758.825 c
157.492 758.489 157.245 758.216 156.844 758.216 c
156.837 758.216 l
f
158.428 759.513 1.215 -5.688 re
f
162.708 755.672 m
162.068 755.672 161.572 755.519 161.572 755.056 c
161.572 754.745 161.78 754.592 162.052 754.592 c
162.348 754.592 162.604 754.791 162.684 755.039 c
162.7 755.103 162.708 755.176 162.708 755.247 c
162.708 755.672 l
h
163.884 754.767 m
163.884 754.4 163.9 754.039 163.948 753.825 c
162.852 753.825 l
162.78 754.216 l
162.757 754.216 l
162.501 753.905 162.1 753.736 161.636 753.736 c
160.845 753.736 160.372 754.312 160.372 754.935 c
160.372 755.953 161.284 756.433 162.669 756.433 c
162.669 756.48 l
162.669 756.687 162.555 756.984 161.956 756.984 c
161.555 756.984 161.132 756.849 160.876 756.697 c
160.652 757.472 l
160.925 757.623 161.46 757.825 162.173 757.825 c
163.475 757.825 163.884 757.056 163.884 756.136 c
163.884 754.767 l
f
166.068 755.489 m
166.068 755.409 166.076 755.336 166.093 755.271 c
166.173 754.953 166.452 754.697 166.803 754.697 c
167.324 754.697 167.643 755.096 167.643 755.8 c
167.643 756.409 167.372 756.888 166.803 756.888 c
166.475 756.888 166.173 756.64 166.093 756.288 c
166.076 756.216 166.068 756.144 166.068 756.064 c
166.068 755.489 l
h
164.852 759.512 m
166.068 759.512 l
166.068 757.271 l
166.083 757.271 l
166.315 757.608 166.723 757.825 167.268 757.825 c
168.204 757.825 168.884 757.048 168.876 755.848 c
168.876 754.441 167.988 753.736 167.093 753.736 c
166.636 753.736 166.188 753.905 165.915 754.369 c
165.899 754.369 l
165.852 753.825 l
164.82 753.825 l
164.837 754.079 164.852 754.552 164.852 754.993 c
164.852 759.512 l
f
169.636 759.513 1.216 -5.688 re
f
174.204 756.224 m
174.204 756.519 174.076 757.016 173.522 757.016 c
173.003 757.016 172.796 756.543 172.764 756.224 c
174.204 756.224 l
h
172.771 755.392 m
172.811 754.888 173.307 754.648 173.876 754.648 c
174.292 754.648 174.628 754.704 174.956 754.816 c
175.116 753.993 l
174.716 753.825 174.227 753.745 173.7 753.745 c
172.372 753.745 171.612 754.512 171.612 755.736 c
171.612 756.728 172.236 757.825 173.587 757.825 c
174.852 757.825 175.333 756.84 175.333 755.871 c
175.333 755.663 175.307 755.48 175.292 755.392 c
172.771 755.392 l
f
179.509 754.609 m
179.988 754.609 180.284 755.079 180.284 755.785 c
180.284 756.361 180.059 756.953 179.509 756.953 c
178.932 756.953 178.708 756.361 178.708 755.777 c
178.708 755.113 178.988 754.609 179.501 754.609 c
179.509 754.609 l
h
179.475 753.736 m
178.333 753.736 177.452 754.489 177.452 755.751 c
177.452 757.016 178.284 757.825 179.548 757.825 c
180.74 757.825 181.54 756.999 181.54 755.816 c
181.54 754.392 180.524 753.736 179.484 753.736 c
179.475 753.736 l
f
182.292 756.489 m
182.292 756.976 182.276 757.384 182.261 757.736 c
183.316 757.736 l
183.372 757.193 l
183.395 757.193 l
183.555 757.449 183.948 757.825 184.602 757.825 c
185.404 757.825 186.003 757.288 186.003 756.136 c
186.003 753.825 l
184.788 753.825 l
184.788 755.993 l
184.788 756.496 184.612 756.84 184.173 756.84 c
183.835 756.84 183.636 756.609 183.548 756.384 c
183.516 756.304 183.509 756.193 183.509 756.079 c
183.509 753.825 l
182.292 753.825 l
182.292 756.489 l
f
186.979 759.513 1.217 -5.688 re
f
189.18 757.737 1.215 -3.912 re
189.78 758.216 m
189.395 758.216 189.148 758.489 189.148 758.825 c
189.148 759.167 189.404 759.432 189.796 759.432 c
190.188 759.432 190.428 759.167 190.436 758.825 c
190.436 758.489 190.188 758.216 189.788 758.216 c
189.78 758.216 l
f
191.371 756.489 m
191.371 756.976 191.355 757.384 191.339 757.736 c
192.395 757.736 l
192.451 757.193 l
192.475 757.193 l
192.636 757.449 193.027 757.825 193.682 757.825 c
194.483 757.825 195.083 757.288 195.083 756.136 c
195.083 753.825 l
193.867 753.825 l
193.867 755.993 l
193.867 756.496 193.69 756.84 193.251 756.84 c
192.915 756.84 192.716 756.609 192.628 756.384 c
192.595 756.304 192.587 756.193 192.587 756.079 c
192.587 753.825 l
191.371 753.825 l
191.371 756.489 l
f
198.428 756.224 m
198.428 756.519 198.3 757.016 197.748 757.016 c
197.227 757.016 197.018 756.543 196.988 756.224 c
198.428 756.224 l
h
196.996 755.392 m
197.036 754.888 197.532 754.648 198.1 754.648 c
198.516 754.648 198.852 754.704 199.18 754.816 c
199.341 753.993 l
198.94 753.825 198.452 753.745 197.925 753.745 c
196.596 753.745 195.837 754.512 195.837 755.736 c
195.837 756.728 196.46 757.825 197.811 757.825 c
199.076 757.825 199.555 756.84 199.555 755.871 c
199.555 755.663 199.532 755.48 199.516 755.392 c
196.996 755.392 l
f
0.957 0.345 0.125 0.027 scn
80.484 760.735 m
80.484 760.299 l
81.761 760.299 l
81.761 760.735 l
81.761 761.789 82.62 762.647 83.674 762.647 c
84.728 762.647 85.588 761.789 85.588 760.735 c
85.588 757.583 l
86.864 757.583 l
86.864 760.735 l
86.864 762.494 85.433 763.925 83.674 763.925 c
81.916 763.925 80.484 762.494 80.484 760.735 c
f
84.733 755.745 m
84.733 755.161 84.261 754.689 83.679 754.689 c
83.097 754.689 82.626 755.161 82.626 755.745 c
82.626 756.327 83.097 756.798 83.679 756.798 c
84.261 756.798 84.733 756.327 84.733 755.745 c
f
81.183 755.755 m
81.183 757.125 82.298 758.24 83.668 758.24 c
85.037 758.24 86.151 757.125 86.151 755.755 c
86.151 754.385 85.037 753.271 83.668 753.271 c
82.298 753.271 81.183 754.385 81.183 755.755 c
h
79.906 755.755 m
79.906 753.68 81.592 751.994 83.668 751.994 c
85.741 751.994 87.429 753.68 87.429 755.755 c
87.429 757.829 85.741 759.517 83.668 759.517 c
81.592 759.517 79.906 757.829 79.906 755.755 c
f
60.654 754.704 m
61.477 754.704 61.95 755.48 61.95 756.536 c
61.95 757.504 61.493 758.335 60.654 758.335 c
59.813 758.335 59.342 757.519 59.342 756.512 c
59.342 755.496 59.83 754.704 60.645 754.704 c
60.654 754.704 l
h
60.59 753.736 m
58.998 753.736 58.054 754.945 58.054 756.48 c
58.054 758.096 59.094 759.304 60.678 759.304 c
62.334 759.304 63.238 758.063 63.238 756.577 c
63.238 754.8 62.174 753.736 60.597 753.736 c
60.59 753.736 l
f
65.246 756.697 m
65.349 756.672 65.47 756.663 65.654 756.663 c
66.302 756.663 66.701 756.993 66.701 757.536 c
66.701 758.033 66.358 758.328 65.741 758.328 c
65.502 758.328 65.332 758.311 65.246 758.288 c
65.246 756.697 l
h
64.037 759.143 m
64.414 759.207 64.942 759.256 65.686 759.256 c
66.436 759.256 66.973 759.113 67.333 758.816 c
67.685 758.552 67.909 758.103 67.909 757.577 c
67.909 757.039 67.741 756.592 67.414 756.296 c
66.998 755.912 66.382 755.728 65.662 755.728 c
65.502 755.728 65.358 755.736 65.246 755.76 c
65.246 753.825 l
64.037 753.825 l
64.037 759.143 l
f
71.893 756.103 m
69.909 756.103 l
69.909 754.825 l
72.125 754.825 l
72.125 753.825 l
68.694 753.825 l
68.694 759.216 l
72.013 759.216 l
72.013 758.216 l
69.909 758.216 l
69.909 757.096 l
71.893 757.096 l
71.893 756.103 l
f
72.958 753.825 m
72.958 759.216 l
74.382 759.216 l
75.501 757.241 l
75.822 756.672 76.134 755.999 76.382 755.392 c
76.397 755.392 l
76.326 756.103 76.301 756.831 76.301 757.647 c
76.301 759.216 l
77.421 759.216 l
77.421 753.825 l
76.141 753.825 l
74.989 755.905 l
74.669 756.489 74.309 757.176 74.053 757.808 c
74.02 757.808 l
74.061 757.088 74.077 756.328 74.077 755.449 c
74.077 753.825 l
72.958 753.825 l
f
92.404 756.12 m
92.068 757.265 l
91.981 757.583 91.884 757.993 91.804 758.305 c
91.78 758.305 l
91.709 757.984 91.62 757.577 91.541 757.265 c
91.213 756.12 l
92.404 756.12 l
h
91.037 755.207 m
90.66 753.825 l
89.397 753.825 l
91.045 759.216 l
92.636 759.216 l
94.316 753.825 l
93.005 753.825 l
92.589 755.207 l
91.037 755.207 l
f
98.789 753.975 m
98.573 753.871 98.061 753.745 97.414 753.745 c
95.548 753.745 94.589 754.912 94.589 756.449 c
94.589 758.281 95.901 759.296 97.533 759.296 c
98.166 759.296 98.644 759.167 98.86 759.063 c
98.605 758.096 l
98.365 758.201 98.02 758.296 97.582 758.296 c
96.621 758.296 95.87 757.712 95.87 756.512 c
95.87 755.441 96.509 754.76 97.589 754.76 c
97.964 754.76 98.365 754.831 98.612 754.935 c
98.789 753.975 l
f
103.309 753.975 m
103.093 753.871 102.582 753.745 101.933 753.745 c
100.068 753.745 99.109 754.912 99.109 756.449 c
99.109 758.281 100.421 759.296 102.053 759.296 c
102.686 759.296 103.166 759.167 103.38 759.063 c
103.125 758.096 l
102.885 758.201 102.541 758.296 102.101 758.296 c
101.141 758.296 100.389 757.712 100.389 756.512 c
100.389 755.441 101.029 754.76 102.109 754.76 c
102.484 754.76 102.885 754.831 103.132 754.935 c
103.309 753.975 l
f
107.324 756.103 m
105.34 756.103 l
105.34 754.825 l
107.556 754.825 l
107.556 753.825 l
104.124 753.825 l
104.124 759.216 l
107.444 759.216 l
107.444 758.216 l
105.34 758.216 l
105.34 757.096 l
107.324 757.096 l
107.324 756.103 l
f
108.428 755.079 m
108.749 754.912 109.26 754.745 109.78 754.745 c
110.34 754.745 110.636 754.975 110.636 755.328 c
110.636 755.663 110.38 755.857 109.732 756.079 c
108.836 756.4 108.245 756.896 108.245 757.681 c
108.245 758.6 109.02 759.296 110.284 759.296 c
110.9 759.296 111.34 759.176 111.66 759.023 c
111.388 758.048 l
111.18 758.152 110.789 758.305 110.268 758.305 c
109.74 758.305 109.484 758.056 109.484 757.785 c
109.484 757.441 109.78 757.288 110.484 757.025 c
111.436 756.672 111.876 756.176 111.876 755.415 c
111.876 754.512 111.188 753.745 109.71 753.745 c
109.092 753.745 108.484 753.912 108.18 754.079 c
108.428 755.079 l
f
112.749 755.079 m
113.068 754.912 113.581 754.745 114.1 754.745 c
114.66 754.745 114.957 754.975 114.957 755.328 c
114.957 755.663 114.7 755.857 114.052 756.079 c
113.156 756.4 112.564 756.896 112.564 757.681 c
112.564 758.6 113.34 759.296 114.604 759.296 c
115.22 759.296 115.66 759.176 115.98 759.023 c
115.709 758.048 l
115.501 758.152 115.108 758.305 114.588 758.305 c
114.06 758.305 113.804 758.056 113.804 757.785 c
113.804 757.441 114.1 757.288 114.804 757.025 c
115.756 756.672 116.196 756.176 116.196 755.415 c
116.196 754.512 115.508 753.745 114.028 753.745 c
113.413 753.745 112.804 753.912 112.501 754.079 c
112.749 755.079 l
f
120.268 759.216 m
123.556 759.216 l
123.556 758.216 l
121.484 758.216 l
121.484 756.984 l
123.42 756.984 l
123.42 755.993 l
121.484 755.993 l
121.484 753.825 l
120.268 753.825 l
120.268 759.216 l
f
124.276 756.449 m
124.276 757.025 124.268 757.4 124.245 757.736 c
125.284 757.736 l
125.332 757.008 l
125.364 757.008 l
125.564 757.583 126.037 757.825 126.42 757.825 c
126.532 757.825 126.588 757.816 126.676 757.8 c
126.676 756.656 l
126.58 756.672 126.484 756.687 126.348 756.687 c
125.9 756.687 125.596 756.455 125.516 756.073 c
125.5 755.993 125.492 755.905 125.492 755.8 c
125.492 753.825 l
124.276 753.825 l
124.276 756.449 l
f
129.62 756.224 m
129.62 756.519 129.492 757.016 128.94 757.016 c
128.42 757.016 128.212 756.543 128.18 756.224 c
129.62 756.224 l
h
128.188 755.392 m
128.228 754.888 128.724 754.648 129.292 754.648 c
129.708 754.648 130.044 754.704 130.372 754.816 c
130.532 753.993 l
130.132 753.825 129.643 753.745 129.116 753.745 c
127.789 753.745 127.028 754.512 127.028 755.736 c
127.028 756.728 127.652 757.825 129.005 757.825 c
130.268 757.825 130.749 756.84 130.749 755.871 c
130.749 755.663 130.724 755.48 130.708 755.392 c
128.188 755.392 l
f
133.845 756.224 m
133.845 756.519 133.716 757.016 133.165 757.016 c
132.643 757.016 132.436 756.543 132.404 756.224 c
133.845 756.224 l
h
132.413 755.392 m
132.452 754.888 132.948 754.648 133.517 754.648 c
133.933 754.648 134.268 754.704 134.597 754.816 c
134.757 753.993 l
134.356 753.825 133.868 753.745 133.341 753.745 c
132.013 753.745 131.253 754.512 131.253 755.736 c
131.253 756.728 131.876 757.825 133.227 757.825 c
134.492 757.825 134.972 756.84 134.972 755.871 c
134.972 755.663 134.948 755.48 134.933 755.392 c
132.413 755.392 l
f
135.7 759.513 1.216 -5.688 re
f
138.811 757.736 m
139.396 755.808 l
139.46 755.583 139.54 755.288 139.589 755.079 c
139.612 755.079 l
139.669 755.296 139.731 755.583 139.788 755.816 c
140.268 757.736 l
141.572 757.736 l
140.66 755.161 l
140.1 753.6 139.723 752.984 139.284 752.592 c
138.868 752.224 138.421 752.088 138.108 752.056 c
137.852 753.079 l
138.005 753.113 138.196 753.183 138.38 753.288 c
138.564 753.384 138.772 753.583 138.884 753.777 c
138.925 753.84 138.948 753.905 138.948 753.953 c
138.948 753.999 138.94 754.056 138.899 754.152 c
137.46 757.736 l
138.811 757.736 l
f
145.78 755.672 m
145.139 755.672 144.643 755.519 144.643 755.056 c
144.643 754.745 144.852 754.592 145.124 754.592 c
145.421 754.592 145.677 754.791 145.757 755.039 c
145.772 755.103 145.78 755.176 145.78 755.247 c
145.78 755.672 l
h
146.956 754.767 m
146.956 754.4 146.972 754.039 147.02 753.825 c
145.925 753.825 l
145.852 754.216 l
145.828 754.216 l
145.572 753.905 145.173 753.736 144.708 753.736 c
143.917 753.736 143.444 754.312 143.444 754.935 c
143.444 755.953 144.356 756.433 145.74 756.433 c
145.74 756.48 l
145.74 756.687 145.628 756.984 145.028 756.984 c
144.628 756.984 144.204 756.849 143.948 756.697 c
143.723 757.472 l
143.997 757.623 144.532 757.825 145.245 757.825 c
146.548 757.825 146.956 757.056 146.956 756.136 c
146.956 754.767 l
f
148.731 757.736 m
149.261 755.92 l
149.356 755.592 149.421 755.281 149.484 754.968 c
149.509 754.968 l
149.572 755.288 149.636 755.583 149.723 755.92 c
150.227 757.736 l
151.509 757.736 l
150.052 753.825 l
148.837 753.825 l
147.413 757.736 l
148.731 757.736 l
f
154.093 755.672 m
153.452 755.672 152.956 755.519 152.956 755.056 c
152.956 754.745 153.164 754.592 153.436 754.592 c
153.732 754.592 153.988 754.791 154.068 755.039 c
154.085 755.103 154.093 755.176 154.093 755.247 c
154.093 755.672 l
h
155.268 754.767 m
155.268 754.4 155.284 754.039 155.332 753.825 c
154.236 753.825 l
154.164 754.216 l
154.139 754.216 l
153.884 753.905 153.484 753.736 153.02 753.736 c
152.227 753.736 151.757 754.312 151.757 754.935 c
151.757 755.953 152.669 756.433 154.052 756.433 c
154.052 756.48 l
154.052 756.687 153.94 756.984 153.341 756.984 c
152.94 756.984 152.516 756.849 152.261 756.697 c
152.036 757.472 l
152.307 757.623 152.845 757.825 153.555 757.825 c
154.86 757.825 155.268 757.056 155.268 756.136 c
155.268 754.767 l
f
156.236 757.737 1.216 -3.912 re
156.837 758.216 m
156.452 758.216 156.204 758.489 156.204 758.825 c
156.204 759.167 156.46 759.432 156.852 759.432 c
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