Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes

Valent, Peter; Klion, Amy D; Horny, Hans-Peter; Roufosse, Florence; Gotlib, Jason; Weller, Peter F; Hellmann, Andrzej; Metzgeroth, Georgia; Leiferman, Kristin M; Arock, Michel; Butterfield, Joseph H; Sperr, Wolfgang R; Sotlar, Karl; Vandenberghe, Peter; Haferlach, Torsten; Simon, Hans-Uwe; Reiter, Andreas; Gleich, Gerald J (2012). Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. Journal of allergy and clinical immunology, 130(3), 607-612.e9. St. Louis, Mo.: Mosby 10.1016/j.jaci.2012.02.019

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Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions. Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to organ dysfunction, clinical symptoms, or both. During the past 2 decades, several different classifications of eosinophilic disorders and related syndromes have been proposed in various fields of medicine. Although criteria and definitions are, in part, overlapping, no global consensus has been presented to date. The Year 2011 Working Conference on Eosinophil Disorders and Syndromes was organized to update and refine the criteria and definitions for eosinophilic disorders and to merge prior classifications in a contemporary multidisciplinary schema. A panel of experts from the fields of immunology, allergy, hematology, and pathology contributed to this project. The expert group agreed on unifying terminologies and criteria and a classification that delineates various forms of hypereosinophilia, including primary and secondary variants based on specific hematologic and immunologic conditions, and various forms of the hypereosinophilic syndrome. For patients in whom no underlying disease or hypereosinophilic syndrome is found, the term hypereosinophilia of undetermined significance is introduced. The proposed novel criteria, definitions, and terminologies should assist in daily practice, as well as in the preparation and conduct of clinical trials.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Simon, Hans-Uwe

ISSN:

0091-6749

Publisher:

Mosby

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:35

Last Modified:

17 Mar 2015 21:25

Publisher DOI:

10.1016/j.jaci.2012.02.019

PubMed ID:

22460074

Web of Science ID:

000308463500005

URI:

https://boris.unibe.ch/id/eprint/14108 (FactScience: 220918)

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