Postoperative radiotherapy after radical prostatectomy: indications and open questions

Ghadjar, Pirus; Zwahlen, Daniel; Aebersold, Daniel; Zimmermann, F. (2012). Postoperative radiotherapy after radical prostatectomy: indications and open questions. Prostate cancer, 2012, p. 963417. New York, N.Y.: Hindawi 10.1155/2012/963417

[img]
Preview
Text
963417.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

Biochemical relapse after radical prostatectomy occurs in approximately 15-40% of patients within 5 years. Postoperative radiotherapy is the only curative treatment for these patients. After radical prostatectomy, two different strategies can be offered, adjuvant or salvage radiotherapy. Adjuvant radiotherapy is defined as treatment given directly after surgery in the presence of risk factors (R1 resection, pT3) before biochemical relapse occurs. It consists of 60-64 Gy and was shown to increase biochemical relapse-free survival in three randomized controlled trials and to increase overall survival after a median followup of 12.7 years in one of these trials. Salvage radiotherapy, on the other hand, is given upon biochemical relapse and is the preferred option, by many centers as it does not include patients who might be cured by surgery alone. As described in only retrospective studies the dose for salvage radiotherapy ranges from 64 to 72 Gy and is usually dependent on the absence or presence of macroscopic recurrence. Randomized trials are currently investigating the role of adjuvant and salvage radiotherapy. Patients with biochemical relapse after prostatectomy should at the earliest sign of relapse be referred to salvage radiotherapy and should preferably be treated within a clinical trial.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Ghadjar, Pirus and Aebersold, Daniel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2090-3111

Publisher:

Hindawi

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:35

Last Modified:

28 Nov 2020 02:20

Publisher DOI:

10.1155/2012/963417

PubMed ID:

22530131

BORIS DOI:

10.7892/boris.14126

URI:

https://boris.unibe.ch/id/eprint/14126 (FactScience: 220942)

Actions (login required)

Edit item Edit item
Provide Feedback